prop-2-en-1-yl 2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoate

Base Information

Chemical Name:prop-2-en-1-yl 2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoate
CAS No.:1369963-17-6
Molecular Formula:C₂₉H₂₉N₅O₆S
Molecular Weight:575.645
Hs Code.:

Synonyms:prop-2-en-1-yl 2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoate

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Chemical Property of prop-2-en-1-yl 2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoate

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Technology Process of prop-2-en-1-yl 2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoate

There total 6 articles about prop-2-en-1-yl 2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369962-48-0
4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoic acid

: 106-49-0,12221-03-3
p-toluidine

: 1369963-17-6
prop-2-en-1-yl 2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoate

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere; Cooling with ice;

Reference yield:

: 62-23-7
4-nitro-benzoic acid

: 1369963-17-6
prop-2-en-1-yl 2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: dmap; di-tert-butyl dicarbonate / tetrahydrofuran / 10 h / 20 °C

1.2: 6 h / 35 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 h / 3102.97 Torr

3.1: pyridine / dichloromethane / 1 h / Cooling with ice

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

5.1: sodium hydroxide; water / ethanol; methanol / 0.5 h / Cooling with ice

6.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 20 °C

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

9.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere; Cooling with ice

With pyridine; dmap; di-tert-butyl dicarbonate; di-isopropyl azodicarboxylate; water; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 19756-72-0
tert-butyl 4-nitrobenzoate

: 1369963-17-6
prop-2-en-1-yl 2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoate

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 h / 3102.97 Torr

2: pyridine / dichloromethane / 1 h / Cooling with ice

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

4: sodium hydroxide; water / ethanol; methanol / 0.5 h / Cooling with ice

5: sodium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 20 °C

6: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C

7: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

8: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere; Cooling with ice

With pyridine; dmap; di-isopropyl azodicarboxylate; water; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;