tert-butyl 4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoate

Base Information

Chemical Name:tert-butyl 4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoate
CAS No.:1369963-16-5
Molecular Formula:C₂₆H₃₀N₄O₇S
Molecular Weight:542.613
Hs Code.:

Synonyms:tert-butyl 4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoate

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Chemical Property of tert-butyl 4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoate

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Technology Process of tert-butyl 4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoate

There total 5 articles about tert-butyl 4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90-16-4
1,2,3-benzotriazin-4(3H)-one

: 1369962-92-4
tert-butyl 4-{[4-hydroxy-1-oxo-1-(prop-2-en-1-yloxy)butan-2-yl](methylsulfonyl)amino}benzoate

: 1369963-16-5
tert-butyl 4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 0.5h;

Reference yield:

: 62-23-7
4-nitro-benzoic acid

: 1369963-16-5
tert-butyl 4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; di-tert-butyl dicarbonate / tetrahydrofuran / 10 h / 20 °C

1.2: 6 h / 35 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 h / 3102.97 Torr

3.1: pyridine / dichloromethane / 1 h / Cooling with ice

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

5.1: sodium hydroxide; water / ethanol; methanol / 0.5 h / Cooling with ice

6.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 20 °C

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C

With pyridine; dmap; di-tert-butyl dicarbonate; di-isopropyl azodicarboxylate; water; hydrogen; sodium hydrogencarbonate; triphenylphosphine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 19756-72-0
tert-butyl 4-nitrobenzoate

: 1369963-16-5
tert-butyl 4-{(methylsulfonyl)[1-oxo-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)-1-(prop-2-en-1-yloxy)butan-2-yl]amino}benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 h / 3102.97 Torr

2: pyridine / dichloromethane / 1 h / Cooling with ice

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

4: sodium hydroxide; water / ethanol; methanol / 0.5 h / Cooling with ice

5: sodium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 20 °C

6: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C

With pyridine; di-isopropyl azodicarboxylate; water; hydrogen; sodium hydrogencarbonate; triphenylphosphine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;