Technology Process of (E)-methyl 5-(2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)phenoxy)pentanoate
There total 9 articles about (E)-methyl 5-(2-(3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-ylthio)phenoxy)pentanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
caesium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
dichloromethane; N,N-dimethyl-formamide;
at 80 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ammonium chloride; iron / ethanol; water / 2 h / 50 °C
2.1: hydrogenchloride; sodium nitrite; acetic acid / water / 0 °C
2.2: 2 h / 0 °C
3.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; N,N-dimethyl-formamide / 16 h / 80 °C
With
hydrogenchloride; iron; ammonium chloride; caesium carbonate; acetic acid; sodium nitrite;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: methanesulfonic acid / dichloromethane; tetrahydrofuran / 5 h / 25 °C
2.1: N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 12 h / 100 °C
3.1: ammonium chloride; iron / ethanol; water / 2 h / 50 °C
4.1: hydrogenchloride; sodium nitrite; acetic acid / water / 0 °C
4.2: 2 h / 0 °C
5.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; N,N-dimethyl-formamide / 16 h / 80 °C
With
hydrogenchloride; methanesulfonic acid; iron; ammonium chloride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; sodium nitrite;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;