8-Bromo-4-chloro-2-methylquinoline

Base Information

• Chemical Name: 8-Bromo-4-chloro-2-methylquinoline
• CAS No.: 1201-07-6
• Molecular Formula: C10H7BrClN
• Molecular Weight: 256.529
• Hs Code.: 2933499090
• European Community (EC) Number: 802-663-9
• DSSTox Substance ID: DTXSID20354310
• Wikidata: Q72453076
• Mol file: 1201-07-6.mol

Synonyms:8-Bromo-4-chloro-2-methylquinoline;1201-07-6;Quinoline, 8-bromo-4-chloro-2-methyl-;2-methyl-4-chloro-8-bromo-quinoline;SCHEMBL317207;DTXSID20354310;SDVHWORPDUOWDV-UHFFFAOYSA-N;HMS1683B15;MFCD00272432;AKOS000618523;AB05684;AC-37177;BS-14541;CS-0134485;FT-0621511;C71676;EN300-627350;8-Bromo-4-chloro-2-methylquinoline, AldrichCPR;AN-584/13369224

Chemical Property of 8-Bromo-4-chloro-2-methylquinoline

Chemical Property:

• Vapor Pressure: 0.000546mmHg at 25°C
• Refractive Index: 1.661
• Boiling Point: 321.854 °C at 760 mmHg
• Flash Point: 148.452 °C
• PSA: 12.89000
• Density: 1.591 g/cm³
• LogP: 3.95910
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 254.94504
• Heavy Atom Count: 13
• Complexity: 188

Purity/Quality:

98%,99%, ^*data from raw suppliers

8-Bromo-4-chloro-2-methylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C2C=CC=C(C2=N1)Br)Cl
• Uses: 8-Bromo-4-chloro-2-methylquinoline is a useful chemical for research.

Technology Process of 8-Bromo-4-chloro-2-methylquinoline

There total 4 articles about 8-Bromo-4-chloro-2-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-methyl-4-hydroxy-8-bromo-quinoline (1201-08-7) → 2-methyl-4-chloro-8-bromo-quinoline (1201-07-6)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 0.5h;

Reference yield:

C12H14BrNO2 (128942-73-4) → 2-methyl-4-chloro-8-bromo-quinoline (1201-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenylether / 0.5 h / Reflux

2: trichlorophosphate / 3 h / Reflux

With trichlorophosphate; In diphenylether;

DOI:10.1007/s00044-011-9854-3

Reference yield:

2-bromoaniline (615-36-1) → 2-methyl-4-chloro-8-bromo-quinoline (1201-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 7 h / 40 °C

2: diphenylether / 0.5 h / Reflux

3: trichlorophosphate / 3 h / Reflux

With trichlorophosphate; In methanol; diphenylether;

DOI:10.1007/s00044-011-9854-3

upstream raw materials:

2-methyl-4-hydroxy-8-bromo-quinoline

C₁₂H₁₄BrNO₂

2-bromoaniline

Downstream raw materials:

4-chloro-2-methyl-8-(2,4,6-trimethyl-phenyl)-quinoline

(8-bromo-2-methylquinolin-4-yl)-(3,4-dichlorobenzyl)-amine