N-[2-(2-chloro-5-methoxy-4-nitro-phenyl)-ethyl]-2-morpholin-4-yl-acetamide

Base Information

Chemical Name:N-[2-(2-chloro-5-methoxy-4-nitro-phenyl)-ethyl]-2-morpholin-4-yl-acetamide
CAS No.:1437717-92-4
Molecular Formula:C₁₅H₂₀ClN₃O₅
Molecular Weight:357.794
Hs Code.:

Synonyms:N-[2-(2-chloro-5-methoxy-4-nitro-phenyl)-ethyl]-2-morpholin-4-yl-acetamide

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Chemical Property of N-[2-(2-chloro-5-methoxy-4-nitro-phenyl)-ethyl]-2-morpholin-4-yl-acetamide

Chemical Property:

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Technology Process of N-[2-(2-chloro-5-methoxy-4-nitro-phenyl)-ethyl]-2-morpholin-4-yl-acetamide

There total 7 articles about N-[2-(2-chloro-5-methoxy-4-nitro-phenyl)-ethyl]-2-morpholin-4-yl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 110-91-8,99108-56-2
morpholine

: 1437717-84-4
2-chloro-N-[2-(2-chloro-5-methoxy-4-nitro-phenyl)-ethyl]-acetamide

: 1437717-92-4
N-[2-(2-chloro-5-methoxy-4-nitro-phenyl)-ethyl]-2-morpholin-4-yl-acetamide

Guidance literature:: With potassium carbonate; In acetonitrile; at 70 ℃; for 8h;

Reference yield:

: 1027833-17-5
1-bromo-2-chloro-5-fluoro-4-nitrobenzene

: 1437717-92-4
N-[2-(2-chloro-5-methoxy-4-nitro-phenyl)-ethyl]-2-morpholin-4-yl-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 0 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / propan-1-ol / 4 h / Reflux

3: quinoline / isopropyl alcohol / 20 h / 70 °C

4: water; ammonium cerium (IV) nitrate / acetonitrile / 2.5 h / 0 - 20 °C

5: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

6: potassium carbonate / acetonitrile / 8 h / 70 °C

With quinoline; ammonium cerium (IV) nitrate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium carbonate; triethylamine; In propan-1-ol; dichloromethane; isopropyl alcohol; acetonitrile;

Reference yield:

: 1437717-45-7
[2-(2-chloro-5-methoxy-4-nitro-phenyl)-ethyl]-(2,4-dimethoxy-benzyl)-amine

: 1437717-92-4
N-[2-(2-chloro-5-methoxy-4-nitro-phenyl)-ethyl]-2-morpholin-4-yl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: water; ammonium cerium (IV) nitrate / acetonitrile / 2.5 h / 0 - 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: potassium carbonate / acetonitrile / 8 h / 70 °C

With ammonium cerium (IV) nitrate; water; potassium carbonate; triethylamine; In dichloromethane; acetonitrile;