3-(2-chloro-4,5-dilfuorophenyl)-3-oxo-2-(ethoxymethylene)propanoic acid ethyl ester

Base Information

• Chemical Name: 3-(2-chloro-4,5-dilfuorophenyl)-3-oxo-2-(ethoxymethylene)propanoic acid ethyl ester
• CAS No.: 121872-98-8
• Molecular Formula: C₁₄H₁₃ClF₂O₄
• Molecular Weight: 318.705

Synonyms:3-(2-chloro-4,5-dilfuorophenyl)-3-oxo-2-(ethoxymethylene)propanoic acid ethyl ester

Chemical Property of 3-(2-chloro-4,5-dilfuorophenyl)-3-oxo-2-(ethoxymethylene)propanoic acid ethyl ester

Chemical Property:

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Technology Process of 3-(2-chloro-4,5-dilfuorophenyl)-3-oxo-2-(ethoxymethylene)propanoic acid ethyl ester

There total 1 articles about 3-(2-chloro-4,5-dilfuorophenyl)-3-oxo-2-(ethoxymethylene)propanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

orthoformic acid triethyl ester (122-51-0) + 2-chloro-4,5-difluoro-β-oxobenzenepropanoic acid ethyl ester (121872-97-7) → 3-(2-chloro-4,5-dilfuorophenyl)-3-oxo-2-(ethoxymethylene)propanoic acid ethyl ester (121872-98-8)

Guidance literature:

With acetic anhydride; at 140 ℃;

DOI:10.1021/jm0205090

Reference yield: 96.0%

2-fluoro-1,1-(dimethyl)-ethylamine hydrochloride (112433-51-9) + 3-(2-chloro-4,5-dilfuorophenyl)-3-oxo-2-(ethoxymethylene)propanoic acid ethyl ester (121872-98-8) → 3-(2-chloro-4,5-difluorophenyl)-3-oxo-2-<<(1,1-dimethyl-2-fluoroethyl)amino>methylene>propanoic acid ethyl ester (130435-34-6)

Guidance literature:

With triethylamine; In ethanol; for 3h;

DOI:10.1021/jm00105a006

Reference yield:

1-cyclobutylethanamine hydrochloride (904733-73-9,1355969-30-0) + 3-(2-chloro-4,5-dilfuorophenyl)-3-oxo-2-(ethoxymethylene)propanoic acid ethyl ester (121872-98-8) → C20H25F2NO4

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

upstream raw materials:

orthoformic acid triethyl ester

2-chloro-4,5-difluoro-β-oxobenzenepropanoic acid ethyl ester

Downstream raw materials:

3-(2-chloro-4,5-difluorophenyl)-3-oxo-2-<<(1,1-dimethyl-2-fluoroethyl)amino>methylene>propanoic acid ethyl ester

(Z)-2-(2-Chloro-4,5-difluoro-benzoyl)-3-(2-fluoro-1,1-bis-fluoromethyl-ethylamino)-acrylic acid ethyl ester

1-(5-amino-2,4-difluorophenyl)-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

ethyl 1-(5-tert-butoxycarbonylamino-2,4-difluorophenyl)-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

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