2-chloro-4,5-difluoro-β-oxobenzenepropanoic acid ethyl ester

Base Information

• Chemical Name: 2-chloro-4,5-difluoro-β-oxobenzenepropanoic acid ethyl ester
• CAS No.: 121872-97-7
• Molecular Formula: C₁₁H₉ClF₂O₃
• Molecular Weight: 262.64
• Mol file: 121872-97-7.mol

Synonyms:2-chloro-4,5-difluoro-β-oxobenzenepropanoic acid ethyl ester

Chemical Property of 2-chloro-4,5-difluoro-β-oxobenzenepropanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-4,5-difluoro-β-oxobenzenepropanoic acid ethyl ester

There total 6 articles about 2-chloro-4,5-difluoro-β-oxobenzenepropanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.8%

methylmagnesium chloride (676-58-4) + ethyl potassium malonate (6148-64-7) + 2-chloro-4,5-difluorobenzoyl chloride (121872-95-5) → 2-chloro-4,5-difluoro-β-oxobenzenepropanoic acid ethyl ester (121872-97-7)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; toluene;

Reference yield: 76.0%

2-(2-Chloro-4,5-difluorobenzoyl)-3-oxobutyric acid ethyl ester → 2-chloro-4,5-difluoro-β-oxobenzenepropanoic acid ethyl ester (121872-97-7)

Guidance literature:

With pyridinium p-toluenesulfonate; In ethanol; for 18h; Heating;

DOI:10.1080/00304949709355192

Reference yield: 67.1%

→ 2-chloro-4,5-difluoro-β-oxobenzenepropanoic acid ethyl ester (121872-97-7)

Guidance literature:

upstream raw materials:

2-chloro-4,5-difluorobenzoyl chloride

(2-chloro-4,5-difluorobenzoyl)propanedioic acid diethyl ester

methylmagnesium chloride

ethyl potassium malonate

Downstream raw materials:

2-chloro-α-(ethoxymethylene)-4,5-difluoro-β-oxobenzenepropanoic acid,ethyl ester

ethyl 1-(5-tert-butoxycarbonylamino-2,4-difluorophenyl)-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

1-(5-amino-2,4-difluorophenyl)-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

3-(2-chloro-4,5-dilfuorophenyl)-3-oxo-2-(ethoxymethylene)propanoic acid ethyl ester

Refernces

• 1、 -. "Preparation of beta-ketoesters useful in preparing quinolone antibiotics". . . Retrieved 2008/06/13.
• 2、 -. "Process for preparing fluorinated benzoyl compounds". . . Retrieved 2008/06/13.