benzyl 5-(4'-(1-(ethoxycarbonyl)cyclopropyl)biphenyl-4-yl)-3-methylisoxazole-4-carboxylate

Base Information

Chemical Name:benzyl 5-(4'-(1-(ethoxycarbonyl)cyclopropyl)biphenyl-4-yl)-3-methylisoxazole-4-carboxylate
CAS No.:1380650-62-3
Molecular Formula:C₃₀H₂₇NO₅
Molecular Weight:481.548
Hs Code.:

Synonyms:benzyl 5-(4'-(1-(ethoxycarbonyl)cyclopropyl)biphenyl-4-yl)-3-methylisoxazole-4-carboxylate

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Chemical Property of benzyl 5-(4'-(1-(ethoxycarbonyl)cyclopropyl)biphenyl-4-yl)-3-methylisoxazole-4-carboxylate

Chemical Property:

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Technology Process of benzyl 5-(4'-(1-(ethoxycarbonyl)cyclopropyl)biphenyl-4-yl)-3-methylisoxazole-4-carboxylate

There total 6 articles about benzyl 5-(4'-(1-(ethoxycarbonyl)cyclopropyl)biphenyl-4-yl)-3-methylisoxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380650-61-2
ethyl 1-(4'-(2-(benzyloxycarbonyl)-3-(methylamino)but-2-enoyl)biphenyl-4-yl)cyclopropanecarboxylate

: 1380650-62-3
benzyl 5-(4'-(1-(ethoxycarbonyl)cyclopropyl)biphenyl-4-yl)-3-methylisoxazole-4-carboxylate

Guidance literature:: With hydroxylamine hydrochloride; In acetic acid; at 95 ℃; for 0.5h;

Reference yield:

: 31603-77-7
4-biphenylacetonitrile

: 1380650-62-3
benzyl 5-(4'-(1-(ethoxycarbonyl)cyclopropyl)biphenyl-4-yl)-3-methylisoxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide; tetrabutylammomium bromide / toluene; water / 48 h / 20 - 80 °C

2.1: potassium hydroxide; water / ethylene glycol / 3 h / 170 °C

3.1: sulfuric acid / 16 h / Reflux

4.1: aluminum (III) chloride / dichloromethane / 2 h / 20 °C

5.1: sodium hydroxide; bromine; water / 1,4-dioxane / 0.5 h / 10 - 20 °C

6.1: thionyl chloride / N,N-dimethyl-formamide; 1,2-dichloro-ethane / 1.5 h / 80 °C

6.2: 2 h / 50 °C

7.1: hydroxylamine hydrochloride / acetic acid / 1 h / 95 °C

With aluminum (III) chloride; thionyl chloride; sulfuric acid; hydroxylamine hydrochloride; tetrabutylammomium bromide; water; bromine; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; dichloromethane; water; ethylene glycol; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1380650-55-4
ethyl 1-(4-phenylphenyl)cyclopropanecarboxylate

: 1380650-62-3
benzyl 5-(4'-(1-(ethoxycarbonyl)cyclopropyl)biphenyl-4-yl)-3-methylisoxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: aluminum (III) chloride / dichloromethane / 2 h / 20 °C

2.1: sodium hydroxide; bromine; water / 1,4-dioxane / 0.5 h / 10 - 20 °C

3.1: thionyl chloride / N,N-dimethyl-formamide; 1,2-dichloro-ethane / 1.5 h / 80 °C

3.2: 2 h / 50 °C

4.1: hydroxylamine hydrochloride / acetic acid / 1 h / 95 °C

With aluminum (III) chloride; thionyl chloride; hydroxylamine hydrochloride; water; bromine; sodium hydroxide; In 1,4-dioxane; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;