C₂₁H₁₇Cl₂NO₄

Base Information Edit

Chemical Name:C₂₁H₁₇Cl₂NO₄
CAS No.:948897-63-0
Molecular Formula:C₂₁H₁₇Cl₂NO₄
Molecular Weight:418.276
Hs Code.:
Mol file:948897-63-0.mol

C<sub>21</sub>H<sub>17</sub>Cl<sub>2</sub>NO<sub>4</sub>

Synonyms:C₂₁H₁₇Cl₂NO₄

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Chemical Property of C₂₁H₁₇Cl₂NO₄ Edit

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Technology Process of C₂₁H₁₇Cl₂NO₄

There total 7 articles about C₂₁H₁₇Cl₂NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 948897-62-9
C₂₃H₂₁Cl₂NO₄

: 948897-63-0
C₂₁H₁₇Cl₂NO₄

Guidance literature:: With hydrogen bromide; In water; acetic acid; at 95 - 95.5 ℃; for 24h;

Reference yield:

: 906794-87-4
methyl 2-chloro-6-(4-chlorophenoxy)nicotinate

: 948897-63-0
C₂₁H₁₇Cl₂NO₄

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride / tetrahydrofuran; diethyl ether / 0.75 h / 25 - 28 °C

1.2: 0.25 h

2.1: sodium hydroxide; water / methanol / 2.5 h / 68 °C

2.2: 68 °C

3.1: trifluorormethanesulfonic acid; trifluoroacetic anhydride / 40 - 55 °C

3.2: 1 h / 0 - 50 °C

4.1: hydrogen bromide; sodium iodide / water; acetic acid / 24.5 h / 95 - 100 °C

With sodium hydroxide; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; trifluorormethanesulfonic acid; water; hydrogen bromide; trifluoroacetic anhydride; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; water; acetic acid; 3.1: Friedel Crafts Acylation;

Reference yield:

: 65515-28-8
methyl 2,6-dichloronicotinate

: 948897-63-0
C₂₁H₁₇Cl₂NO₄

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 - 22 °C

1.2: 4 - 5 h / 22 - 24 °C

1.3: 3 h / 20 - 25 °C

2.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride / tetrahydrofuran; diethyl ether / 0.75 h / 25 - 28 °C

2.2: 0.25 h

3.1: sodium hydroxide; water / methanol / 2.5 h / 68 °C

3.2: 68 °C

4.1: trifluorormethanesulfonic acid; trifluoroacetic anhydride / 40 - 55 °C

4.2: 1 h / 0 - 50 °C

5.1: hydrogen bromide; sodium iodide / water; acetic acid / 24.5 h / 95 - 100 °C

With sodium hydroxide; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; trifluorormethanesulfonic acid; water; hydrogen bromide; triethylamine; trifluoroacetic anhydride; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; water; acetic acid; N,N-dimethyl-formamide; 4.1: Friedel Crafts Acylation;