9H-Purine, 9-[3-O-benzoyl-2-deoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-arabinofuranosyl]-6-chloro-

Base Information

• Chemical Name: 9H-Purine, 9-[3-O-benzoyl-2-deoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-arabinofuranosyl]-6-chloro-
• CAS No.: 234436-49-8
• Molecular Formula: C36H28 Cl F N4 O4
• Molecular Weight: 635.094

Synonyms:9H-Purine, 9-[3-O-benzoyl-2-deoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-arabinofuranosyl]-6-chloro-

Chemical Property of 9H-Purine, 9-[3-O-benzoyl-2-deoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-arabinofuranosyl]-6-chloro-

Chemical Property:

• PSA: 88.36000
• LogP: 6.94950

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9H-Purine, 9-[3-O-benzoyl-2-deoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-arabinofuranosyl]-6-chloro-

There total 15 articles about 9H-Purine, 9-[3-O-benzoyl-2-deoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-arabinofuranosyl]-6-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5'-O-trityl-3'-O-benzoyl-2'-O-trifluoromethanesulfonyl-6-chloropurine riboside (339196-22-4) → 9-[3-O-benzoyl-2-deoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-arabinofuranosyl]-6-chloro-9H-purine (234436-49-8)

Guidance literature:

With triethylamine hydrofluoride; triethylamine; In ethyl acetate; Heating;

DOI:10.1081/NCN-120021951

Reference yield: 86.0%

9-[3-O-benzoyl-5-O-(triphenylmethyl)-β-D-ribofuranosyl]-6-chloro-9H-purine (234436-48-7) → 9-[3-O-benzoyl-2-deoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-arabinofuranosyl]-6-chloro-9H-purine (234436-49-8)

Guidance literature:

With pyridine; diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 20 ℃; Heating / reflux;

Reference yield: 81.0%

5'-O-trityl-3'-O-benzoyl-2'-O-sulfurylimidazolyl-6-chloropurine riboside + triethylamine tris(hydrogen fluoride) (73602-61-6,23588-89-8,29585-72-6,94527-74-9) → 9-[3-O-benzoyl-2-deoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-arabinofuranosyl]-6-chloro-9H-purine (234436-49-8)

Guidance literature:

In toluene; acetonitrile;

upstream raw materials:

9-[3-O-benzoyl-5-O-(triphenylmethyl)-β-D-ribofuranosyl]-6-chloro-9H-purine

Benzoic acid (2R,3R,4R,5R)-5-(6-chloro-purin-9-yl)-4-(imidazole-1-sulfonyloxy)-2-trityloxymethyl-tetrahydro-furan-3-yl ester

5'-O-trityl-3'-O-benzoyl-2'-O-trifluoromethanesulfonyl-6-chloropurine riboside

trityl chloride

Downstream raw materials:

9-(5-O-trityl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine

iodenosine

9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine-6-amine

9-(3-O-phenoxythiocarbonyl-5-O-trityl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine

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