[8-(4-chlorobenzoyl)-5-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-7-ylidene]acetonitrile

Base Information

• Chemical Name: [8-(4-chlorobenzoyl)-5-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-7-ylidene]acetonitrile
• CAS No.: 748815-90-9
• Molecular Formula: C₂₂H₁₆ClN₃O
• Molecular Weight: 373.842

Synonyms:[8-(4-chlorobenzoyl)-5-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-7-ylidene]acetonitrile

Chemical Property of [8-(4-chlorobenzoyl)-5-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-7-ylidene]acetonitrile

Chemical Property:

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Technology Process of [8-(4-chlorobenzoyl)-5-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-7-ylidene]acetonitrile

There total 2 articles about [8-(4-chlorobenzoyl)-5-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-7-ylidene]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

6-phenyl-3-cyano-4-methylsulfanyl-2H-pyran-2-one (61380-85-6) + 2-(p-chlorobenzoylmethylene)imidazolidine (107165-82-2) → [8-(4-chlorobenzoyl)-5-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-7-ylidene]acetonitrile (748815-90-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 - 25 ℃; for 10h;

DOI:10.1016/j.tetlet.2004.06.015

Reference yield:

1-(4-chlorophenyl)-3,3-bis(methylsulfanyl)-2-propen-1-one (41467-26-9) → [8-(4-chlorobenzoyl)-5-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-7-ylidene]acetonitrile (748815-90-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / ethanol / Heating

2: 52 percent / NaH / tetrahydrofuran / 12 h / 5 - 25 °C

With sodium hydride; In tetrahydrofuran; ethanol;

DOI:10.1016/j.tet.2005.02.012

Reference yield: 49.0%

[8-(4-chlorobenzoyl)-5-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-7-ylidene]acetonitrile (748815-90-9) → 8-chloro-11-oxo-4-phenyl-1,2,3,11-tetrahydro-1,3a-diaza-cyclopenta[a]anthracene-6-carbonitrile

Guidance literature:

In acetonitrile; for 10h; Irradiation;

DOI:10.1016/j.tetlet.2004.06.015

upstream raw materials:

6-phenyl-3-cyano-4-methylsulfanyl-2H-pyran-2-one

2-(p-chlorobenzoylmethylene)imidazolidine

1-(4-chlorophenyl)-3,3-bis(methylsulfanyl)-2-propen-1-one

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