methyl -glycinate

Base Information

• Chemical Name: methyl -glycinate
• CAS No.: 174466-48-9
• Molecular Formula: C₈H₁₆N₂O₆S
• Molecular Weight: 268.291
• Mol file: 174466-48-9.mol

Synonyms:methyl -glycinate

Chemical Property of methyl -glycinate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

N-(N-Boc-sulfamoyl)glycineMethylEster 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl -glycinate

There total 3 articles about methyl -glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

isocyanate de chlorosulfonyle (1189-71-5) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + tert-butyl alcohol (75-65-0) → methyl -glycinate (174466-48-9)

Guidance literature:

isocyanate de chlorosulfonyle; tert-butyl alcohol; In dichloromethane; Cooling with ice;

glycine ethyl ester hydrochloride; With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2012.01.030

Reference yield:

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + N-tert-butyloxycarbonylsulfamoyl chloride (147000-89-3) → methyl -glycinate (174466-48-9)

Guidance literature:

With triethylamine; In dichloromethane; at 5 - 20 ℃;

DOI:10.1016/S0040-4020(99)01025-X

Reference yield:

isocyanate de chlorosulfonyle (1189-71-5) + methoxycarbonylmethylamine (616-34-2) + tert-butyl alcohol (75-65-0) → methyl -glycinate (174466-48-9)

Guidance literature:

With triethylamine;

DOI:10.1016/j.bmc.2012.10.048

upstream raw materials:

isocyanate de chlorosulfonyle

glycine ethyl ester hydrochloride

tert-butyl alcohol

N-tert-butyloxycarbonylsulfamoyl chloride

Downstream raw materials:

methyl -glycinate

C₁₄H₂₁ClN₂O₄S

tert-butyl 1,2,5-thiadiazolidine-2-carboxylate1,1-dioxide

2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)(methyl)amino)acetic acid