N-(3-amino-6-(2-chlorophenyl)-2-methoxypyridin-4-yl)-3-tert-butyl-4-chloro-1-methyl-1H-pyrazole-5-carboxamide

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Chemical Name:N-(3-amino-6-(2-chlorophenyl)-2-methoxypyridin-4-yl)-3-tert-butyl-4-chloro-1-methyl-1H-pyrazole-5-carboxamide
CAS No.:1332877-05-0
Molecular Formula:C₂₁H₂₃Cl₂N₅O₂
Molecular Weight:448.352
Hs Code.:

Synonyms:N-(3-amino-6-(2-chlorophenyl)-2-methoxypyridin-4-yl)-3-tert-butyl-4-chloro-1-methyl-1H-pyrazole-5-carboxamide

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Chemical Property of N-(3-amino-6-(2-chlorophenyl)-2-methoxypyridin-4-yl)-3-tert-butyl-4-chloro-1-methyl-1H-pyrazole-5-carboxamide

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Technology Process of N-(3-amino-6-(2-chlorophenyl)-2-methoxypyridin-4-yl)-3-tert-butyl-4-chloro-1-methyl-1H-pyrazole-5-carboxamide

There total 10 articles about N-(3-amino-6-(2-chlorophenyl)-2-methoxypyridin-4-yl)-3-tert-butyl-4-chloro-1-methyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332876-27-3
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-2-methoxy-3-nitro-pyridin-4-yl]-amide

: 1332877-05-0
N-(3-amino-6-(2-chlorophenyl)-2-methoxypyridin-4-yl)-3-tert-butyl-4-chloro-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: With hydrogen; Pt(sulfided)/C; In ethyl acetate; for 3h; under 1810.07 - 2068.65 Torr;

Reference yield:

: 133261-10-6
5-tert-butyl-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

: 1332877-05-0
N-(3-amino-6-(2-chlorophenyl)-2-methoxypyridin-4-yl)-3-tert-butyl-4-chloro-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuryl dichloride / dichloromethane / 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 4 h / 20 °C

2.2: pH 7

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

4.1: tetrahydrofuran; mineral oil / 0 - 20 °C

5.1: hydrogen / Pt(sulfided)/C / ethyl acetate / 3 h / 1810.07 - 2068.65 Torr

With sulfuryl dichloride; oxalyl dichloride; water; hydrogen; N,N-dimethyl-formamide; sodium hydroxide; Pt(sulfided)/C; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; mineral oil;

Reference yield:

: 13395-36-3
ethyl trimethylacetopyruvate

: 1332877-05-0
N-(3-amino-6-(2-chlorophenyl)-2-methoxypyridin-4-yl)-3-tert-butyl-4-chloro-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 20 - 80 °C

2.1: sulfuryl dichloride / dichloromethane / 20 °C / Inert atmosphere

3.1: sodium hydroxide; water / methanol / 4 h / 20 °C

3.2: pH 7

4.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

5.1: tetrahydrofuran; mineral oil / 0 - 20 °C

6.1: hydrogen / Pt(sulfided)/C / ethyl acetate / 3 h / 1810.07 - 2068.65 Torr

With sulfuryl dichloride; oxalyl dichloride; water; hydrogen; N,N-dimethyl-formamide; sodium hydroxide; Pt(sulfided)/C; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; mineral oil;