5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-2-methoxy-3-nitro-pyridin-4-yl]-amide

Base Information

Chemical Name:5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-2-methoxy-3-nitro-pyridin-4-yl]-amide
CAS No.:1332876-27-3
Molecular Formula:C₂₁H₂₁Cl₂N₅O₄
Molecular Weight:478.335
Hs Code.:

Synonyms:5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-2-methoxy-3-nitro-pyridin-4-yl]-amide

Suppliers and Price of 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-2-methoxy-3-nitro-pyridin-4-yl]-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-2-methoxy-3-nitro-pyridin-4-yl]-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-2-methoxy-3-nitro-pyridin-4-yl]-amide

There total 9 articles about 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-2-methoxy-3-nitro-pyridin-4-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 286837-90-9
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carbonyl chloride

: 1332876-26-2
6-(2-chloro-phenyl)-2-methoxy-3-nitro-pyridin-4-ylamine

: 1332876-27-3
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-2-methoxy-3-nitro-pyridin-4-yl]-amide

Guidance literature:: 6-(2-chloro-phenyl)-2-methoxy-3-nitro-pyridin-4-ylamine; With sodium hydride; In tetrahydrofuran; at 3 - 7 ℃;

5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carbonyl chloride; In tetrahydrofuran; at 1 - 10 ℃; for 1h;

Reference yield:

: 286837-90-9
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carbonyl chloride

: C₁₂H₉ClN₃O₃^(1-)*Na⁽¹⁺⁾

: 1332876-27-3
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-2-methoxy-3-nitro-pyridin-4-yl]-amide

Guidance literature:: In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

Reference yield:

: 2897-43-0
2,6-dichloro-3-nitropyridin-4-amine

: 1332876-27-3
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-(2-chloro-phenyl)-2-methoxy-3-nitro-pyridin-4-yl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 2 h / 100 °C / Sealed tube

2.1: caesium carbonate / 1,4-dioxane; water / 15 h / 90 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 3 - 7 °C

3.2: 1 h / 1 - 10 °C

With sodium hydride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; water; 2.1: Suzuki Coupling;