methyl 3-(2-chloro-4-(methylthio)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate

Base Information

Chemical Name:methyl 3-(2-chloro-4-(methylthio)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate
CAS No.:219764-90-6
Molecular Formula:C₁₇H₁₆ClN₃O₂S
Molecular Weight:361.852
Hs Code.:

Synonyms:methyl 3-(2-chloro-4-(methylthio)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate

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Chemical Property of methyl 3-(2-chloro-4-(methylthio)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate

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Technology Process of methyl 3-(2-chloro-4-(methylthio)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate

There total 11 articles about methyl 3-(2-chloro-4-(methylthio)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27048-04-0
2-amino-6-chloro-3-nitropyridine

: 219764-90-6
methyl 3-(2-chloro-4-(methylthio)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen bromide / acetic acid / 13 h / 90 - 100 °C

4: 1,3-bis-(diphenylphosphino)propane; triethylamine / palladium diacetate / DMF (N,N-dimethyl-formamide) / 14 h / 85 °C / 7600.51 Torr

With 1,3-bis-(diphenylphosphino)propane; hydrogen bromide; triethylamine; palladium diacetate; In DMF (N,N-dimethyl-formamide); acetic acid;

Reference yield:

: 55304-80-8
2,6-dibromo-3-nitropyridine

: 219764-90-6
methyl 3-(2-chloro-4-(methylthio)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonia / ethanol / 19 h / 20 °C

2: sulfuric acid / acetic acid / 0.67 h / 65 °C

4: 1,3-bis-(diphenylphosphino)propane; triethylamine / palladium diacetate / DMF (N,N-dimethyl-formamide) / 14 h / 85 °C / 7600.51 Torr

With sulfuric acid; 1,3-bis-(diphenylphosphino)propane; ammonia; triethylamine; palladium diacetate; In DMF (N,N-dimethyl-formamide); ethanol; acetic acid;

Reference yield:

: 84487-04-7
6-bromo-3-nitro-pyridin-2-ylamine

: 219764-90-6
methyl 3-(2-chloro-4-(methylthio)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; iron / ethanol; water / 2 h / 20 °C / Heating / reflux

2: acetic acid / 29 h / Heating / reflux

3: 1,3-bis-(diphenylphosphino)propane; triethylamine / palladium diacetate / DMF (N,N-dimethyl-formamide) / 14 h / 85 °C / 7600.51 Torr

With hydrogenchloride; 1,3-bis-(diphenylphosphino)propane; iron; triethylamine; palladium diacetate; In DMF (N,N-dimethyl-formamide); ethanol; water; acetic acid;