tert-butyl 3-(3-bromo-2-(4-fluorophenyl)furo[2,3-b]pyridin-5-yl)-4-methylbenzoate

Base Information

Chemical Name:tert-butyl 3-(3-bromo-2-(4-fluorophenyl)furo[2,3-b]pyridin-5-yl)-4-methylbenzoate
CAS No.:1215107-05-3
Molecular Formula:C₂₅H₂₁BrFNO₃
Molecular Weight:482.349
Hs Code.:

Synonyms:tert-butyl 3-(3-bromo-2-(4-fluorophenyl)furo[2,3-b]pyridin-5-yl)-4-methylbenzoate

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Chemical Property of tert-butyl 3-(3-bromo-2-(4-fluorophenyl)furo[2,3-b]pyridin-5-yl)-4-methylbenzoate

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Technology Process of tert-butyl 3-(3-bromo-2-(4-fluorophenyl)furo[2,3-b]pyridin-5-yl)-4-methylbenzoate

There total 7 articles about tert-butyl 3-(3-bromo-2-(4-fluorophenyl)furo[2,3-b]pyridin-5-yl)-4-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1215107-75-7
3-(2-(4-fluorophenyl)-3-(methylcarbamoyl)furo[2,3-c]pyridin-5-yl)benzoic acid

: 36805-97-7
N,N-dimethylformamide di-tert-butyl acetal

: 1215107-05-3
tert-butyl 3-(3-bromo-2-(4-fluorophenyl)furo[2,3-b]pyridin-5-yl)-4-methylbenzoate

Guidance literature:: In toluene; at 80 ℃; for 1h;

Reference yield: 70.0%

: 1215107-03-1
3-(3-bromo-2-(4-fluorophenyl)furo[2,3-b]pyridin-5-yl)-4-methylbenzoic acid

: 36805-97-7
N,N-dimethylformamide di-tert-butyl acetal

: 1215107-05-3
tert-butyl 3-(3-bromo-2-(4-fluorophenyl)furo[2,3-b]pyridin-5-yl)-4-methylbenzoate

Guidance literature:: In toluene; at 80 ℃; for 1h;

Reference yield:

: 766-98-3
1-ethynyl-4-fluorobenzene

: 1215107-05-3
tert-butyl 3-(3-bromo-2-(4-fluorophenyl)furo[2,3-b]pyridin-5-yl)-4-methylbenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; copper(l) iodide / trans-bis(triphenylphosphine)palladium dichloride / 2 h / 90 °C / Inert atmosphere

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 90 °C

2.2: 1 h

3.1: N-Bromosuccinimide / 1,2-dichloro-ethane / 20 °C / flask was wrapped in aluminum foil

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 60 °C

5.1: toluene / 1 h / 80 °C

With N-Bromosuccinimide; copper(l) iodide; water; caesium carbonate; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1,2-dichloro-ethane; toluene;