Technology Process of methyl 5-(5-(tert-butoxycarbonyl)-2-methylphenyl)-2-(4-fluorophenyl)furo[2,3-b]pyridine-3-carboxylate
There total 7 articles about methyl 5-(5-(tert-butoxycarbonyl)-2-methylphenyl)-2-(4-fluorophenyl)furo[2,3-b]pyridine-3-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,3-bis-(diphenylphosphino)propane;
palladium diacetate;
In
dimethyl sulfoxide;
at 80 ℃;
under 15514.9 Torr;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine; copper(l) iodide / trans-bis(triphenylphosphine)palladium dichloride / 2 h / 90 °C / Inert atmosphere
2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 90 °C
2.2: 1 h
3.1: N-Bromosuccinimide / 1,2-dichloro-ethane / 20 °C / flask was wrapped in aluminum foil
4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 60 °C
5.1: toluene / 1 h / 80 °C
6.1: 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 80 °C / 15514.9 Torr / Parr bomb
With
N-Bromosuccinimide; copper(l) iodide; 1,3-bis-(diphenylphosphino)propane; water; caesium carbonate; triethylamine; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0); trans-bis(triphenylphosphine)palladium dichloride; palladium diacetate;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine; copper(l) iodide / trans-bis(triphenylphosphine)palladium dichloride / 2 h / 90 °C / Inert atmosphere
2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 90 °C
2.2: 1 h
3.1: N-Bromosuccinimide / 1,2-dichloro-ethane / 20 °C / flask was wrapped in aluminum foil
4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 60 °C
5.1: toluene / 1 h / 80 °C
6.1: 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 80 °C / 15514.9 Torr / Parr bomb
With
N-Bromosuccinimide; copper(l) iodide; 1,3-bis-(diphenylphosphino)propane; water; caesium carbonate; triethylamine; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0); trans-bis(triphenylphosphine)palladium dichloride; palladium diacetate;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;
