3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide
CAS No.:1282606-73-8
Molecular Formula:C₂₇H₂₄FN₇O₃
Molecular Weight:513.531
Hs Code.:

Synonyms:3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide

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Chemical Property of 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide

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Technology Process of 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide

There total 7 articles about 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3731-52-0
3-Aminomethylpyridine

: 1282606-69-2
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylic acid

: 1282606-73-8
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 625386-10-9
2-(4-methoxybenzyl)-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester

: 1282606-73-8
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

2.1: pyridine / dichloromethane / 0 - 20 °C

2.2: 1 h / 20 °C

3.1: toluene-4-sulfonic acid / methanol / 0.17 h / 90 °C / microwave irradiation

4.1: potassium carbonate / acetone / 3.5 h / Reflux

5.1: sodium hydroxide / ethanol / 2 h / Reflux

5.2: pH 2 - 3

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 3 h / 20 °C

With pyridine; hydrogen; potassium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetone;

Reference yield:

: 1282606-65-8
methyl 3-(hydrazinecarboxamido)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

: 1282606-73-8
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / methanol / 0.17 h / 90 °C / microwave irradiation

2.1: potassium carbonate / acetone / 3.5 h / Reflux

3.1: sodium hydroxide / ethanol / 2 h / Reflux

3.2: pH 2 - 3

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 3 h / 20 °C

With potassium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; acetone;