methyl 3-(hydrazinecarboxamido)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

Base Information

Chemical Name:methyl 3-(hydrazinecarboxamido)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate
CAS No.:1282606-65-8
Molecular Formula:C₁₄H₁₇N₅O₄
Molecular Weight:319.32
Hs Code.:

Synonyms:methyl 3-(hydrazinecarboxamido)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

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Chemical Property of methyl 3-(hydrazinecarboxamido)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

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Technology Process of methyl 3-(hydrazinecarboxamido)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

There total 5 articles about methyl 3-(hydrazinecarboxamido)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 7693-46-1
4-Nitrophenyl chloroformate

: 625386-12-1
5-amino-2-(p-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

: 1282606-65-8
methyl 3-(hydrazinecarboxamido)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

Guidance literature:: 4-Nitrophenyl chloroformate; 5-amino-2-(p-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester; With pyridine; In dichloromethane; at 0 - 20 ℃;

With hydrazine hydrate; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: C₂₀H₁₈N₄O₇

: 1282606-65-8
methyl 3-(hydrazinecarboxamido)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

Guidance literature:: With hydrazine hydrate; In tetrahydrofuran; dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2014.12.014

Reference yield:

: 181585-93-3
5-nitro-2H-pyrazole-3-carboxylic acid methyl ester

: 1282606-65-8
methyl 3-(hydrazinecarboxamido)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrahydrofuran / 2 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

3.1: pyridine / dichloromethane / 0 - 20 °C

3.2: 1 h / 20 °C

With pyridine; hydrogen; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;