(1R,3S,4R,4aS,17aR)-4-Benzyloxy-3-methoxy-11-(toluene-4-sulfonyl)-1-trityloxymethyl-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

Base Information

Chemical Name:(1R,3S,4R,4aS,17aR)-4-Benzyloxy-3-methoxy-11-(toluene-4-sulfonyl)-1-trityloxymethyl-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene
CAS No.:332057-86-0
Molecular Formula:C₄₈H₅₅NO₁₀S
Molecular Weight:838.031
Hs Code.:

(1R,3S,4R,4aS,17aR)-4-Benzyloxy-3-methoxy-11-(toluene-4-sulfonyl)-1-trityloxymethyl-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

Synonyms:(1R,3S,4R,4aS,17aR)-4-Benzyloxy-3-methoxy-11-(toluene-4-sulfonyl)-1-trityloxymethyl-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

Suppliers and Price of (1R,3S,4R,4aS,17aR)-4-Benzyloxy-3-methoxy-11-(toluene-4-sulfonyl)-1-trityloxymethyl-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,3S,4R,4aS,17aR)-4-Benzyloxy-3-methoxy-11-(toluene-4-sulfonyl)-1-trityloxymethyl-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1R,3S,4R,4aS,17aR)-4-Benzyloxy-3-methoxy-11-(toluene-4-sulfonyl)-1-trityloxymethyl-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

There total 7 articles about (1R,3S,4R,4aS,17aR)-4-Benzyloxy-3-methoxy-11-(toluene-4-sulfonyl)-1-trityloxymethyl-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 70-55-3
toluene-4-sulfonamide

: 332057-69-9
(2S,3R,4S,5R,6R)-3-Benzyloxy-4,5-bis-[2-(2-chloro-ethoxy)-ethoxy]-2-methoxy-6-trityloxymethyl-tetrahydro-pyran

: 332057-86-0
(1R,3S,4R,4aS,17aR)-4-Benzyloxy-3-methoxy-11-(toluene-4-sulfonyl)-1-trityloxymethyl-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 36h;
DOI:10.3987/COM-00-9098

Reference yield:

: 53958-32-0,15038-69-4,81348-16-5,86427-99-8,100662-84-8
methyl α-D-glucopyranoside 2-benzyl ether

: 332057-86-0
(1R,3S,4R,4aS,17aR)-4-Benzyloxy-3-methoxy-11-(toluene-4-sulfonyl)-1-trityloxymethyl-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 8 h / 40 °C

2: 2 h / 20 °C

3: 83 percent / aq. NaOH; NBu₄*HSO₄ / 12 h / 20 °C

4: 72 percent / K₂CO₃ / dimethylformamide / 36 h / 120 °C

With pyridine; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.3987/COM-00-9098

Reference yield:

: 100-39-0
benzyl bromide

: 332057-86-0
(1R,3S,4R,4aS,17aR)-4-Benzyloxy-3-methoxy-11-(toluene-4-sulfonyl)-1-trityloxymethyl-dodecahydro-2,5,8,14,17-pentaoxa-11-aza-benzocyclopentadecene

Guidance literature:: Multi-step reaction with 6 steps

1.1: Bu₂SnO / methanol / 1 h / Heating

1.2: 83 percent / 11 h / 110 °C

2.1: 100 percent / aq. HCl / tetrahydrofuran; methanol / 4 h / Heating

3.1: pyridine / 8 h / 40 °C

4.1: 2 h / 20 °C

5.1: 83 percent / aq. NaOH; NBu₄*HSO₄ / 12 h / 20 °C

6.1: 72 percent / K₂CO₃ / dimethylformamide / 36 h / 120 °C

With pyridine; hydrogenchloride; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; di(n-butyl)tin oxide; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.3987/COM-00-9098