8-bromo-3-(tert-butyl)-6-(4-fluorophenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine

Base Information

Chemical Name:8-bromo-3-(tert-butyl)-6-(4-fluorophenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine
CAS No.:1609654-86-5
Molecular Formula:C₁₈H₁₉BrFNO
Molecular Weight:364.257
Hs Code.:

Synonyms:8-bromo-3-(tert-butyl)-6-(4-fluorophenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine

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Chemical Property of 8-bromo-3-(tert-butyl)-6-(4-fluorophenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine

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Technology Process of 8-bromo-3-(tert-butyl)-6-(4-fluorophenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine

There total 1 articles about 8-bromo-3-(tert-butyl)-6-(4-fluorophenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 35770-89-9
3-bromo-4'-fluoro-[1,1'-biphenyl]-4-ol

: 75-64-9
tert-butylamine

: 1609654-86-5
8-bromo-3-(tert-butyl)-6-(4-fluorophenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine

Guidance literature:: formaldehyd; tert-butylamine; In isopropyl alcohol; at 80 ℃; for 1h; Inert atmosphere;

3-bromo-4'-fluoro-[1,1'-biphenyl]-4-ol; In isopropyl alcohol; at 80 ℃; for 72h; Inert atmosphere;

Reference yield: 37.0%

: 868662-36-6
6-(trifluoromethyl)-3-pyridinylboronic acid

: 1609654-86-5
8-bromo-3-(tert-butyl)-6-(4-fluorophenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine

: 1609654-87-6
3-(tert-butyl)-6-(4-fluorophenyl)-8-(6-(trifluoromethyl)pyridin-3-yl)-3,4-dihydro-2H-benzo[e][1,3]oxazine

Guidance literature:: 6-(trifluoromethyl)-3-pyridinylboronic acid; 8-bromo-3-(tert-butyl)-6-(4-fluorophenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine; With potassium carbonate; In 1,2-dimethoxyethane; water; for 0.333333h; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 17h; Inert atmosphere; Sealed tube;

Reference yield:

: 868662-36-6
6-(trifluoromethyl)-3-pyridinylboronic acid

: 1609654-86-5
8-bromo-3-(tert-butyl)-6-(4-fluorophenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine

: 1609655-28-8
3-((tert-butylamino)methyl)-4'-fluoro-5-(6-(trifluoromethyl)pyridin-3-yl)-[1,1'-biphenyl]-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.33 h / Inert atmosphere

1.2: 17 h / 80 °C / Inert atmosphere; Sealed tube

2.1: hydrogenchloride / ethanol / 144 h / 20 °C

With hydrogenchloride; potassium carbonate; In 1,2-dimethoxyethane; ethanol; water; 1.1: |Suzuki Coupling / 1.2: |Suzuki Coupling;