2-{[1-Phenyl-meth-(E)-ylidene]-amino}-octanedioic acid 8-benzyl ester 1-ethyl ester

Base Information

• Chemical Name: 2-{[1-Phenyl-meth-(E)-ylidene]-amino}-octanedioic acid 8-benzyl ester 1-ethyl ester
• CAS No.: 84175-16-6
• Molecular Formula: C₂₄H₂₉NO₄
• Molecular Weight: 395.499
• Mol file: 84175-16-6.mol

Synonyms:2-{[1-Phenyl-meth-(E)-ylidene]-amino}-octanedioic acid 8-benzyl ester 1-ethyl ester

Chemical Property of 2-{[1-Phenyl-meth-(E)-ylidene]-amino}-octanedioic acid 8-benzyl ester 1-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-{[1-Phenyl-meth-(E)-ylidene]-amino}-octanedioic acid 8-benzyl ester 1-ethyl ester

There total 3 articles about 2-{[1-Phenyl-meth-(E)-ylidene]-amino}-octanedioic acid 8-benzyl ester 1-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromohexanoic acid (4224-70-8) → 2-{[1-Phenyl-meth-(E)-ylidene]-amino}-octanedioic acid 8-benzyl ester 1-ethyl ester (84175-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 84.4 percent / p-TsOH*H₂O / benzene / 6 h / Heating

2: 1.) K tert-butoxide / 1.) THF, -78 deg C, 10-20 min, 2.) THF, -78 deg C, 15-20 min, 25 deg C, 1-2 h

With potassium tert-butylate; toluene-4-sulfonic acid; In benzene;

DOI:10.1021/jo00152a005

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 2-{[1-Phenyl-meth-(E)-ylidene]-amino}-octanedioic acid 8-benzyl ester 1-ethyl ester (84175-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 84.4 percent / p-TsOH*H₂O / benzene / 6 h / Heating

2: 1.) K tert-butoxide / 1.) THF, -78 deg C, 10-20 min, 2.) THF, -78 deg C, 15-20 min, 25 deg C, 1-2 h

With potassium tert-butylate; toluene-4-sulfonic acid; In benzene;

DOI:10.1021/jo00152a005

Reference yield:

ethyl N-benzylideneglycinate (40682-54-0) + benzyl 6-bromohexanoate (78277-26-6) → 2-{[1-Phenyl-meth-(E)-ylidene]-amino}-octanedioic acid 8-benzyl ester 1-ethyl ester (84175-16-6)

Guidance literature:

With potassium tert-butylate; Yield given. Multistep reaction; 1.) THF, -78 deg C, 10-20 min, 2.) THF, -78 deg C, 15-20 min, 25 deg C, 1-2 h;

DOI:10.1021/jo00152a005

upstream raw materials:

ethyl N-benzylideneglycinate

benzyl 6-bromohexanoate

6-bromohexanoic acid

benzyl alcohol

Downstream raw materials:

α-Ethyl ω-benzyl DL-α-aminosuberate hydrochloride

α-Ethyl ω-benzyl DL-α-(acetylamino)suberate