(2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoic acid

Base Information

Chemical Name:(2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoic acid
CAS No.:1370478-44-6
Molecular Formula:C₂₂H₁₉F₃N₂O₄
Molecular Weight:432.399
Hs Code.:

Synonyms:(2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoic acid

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Chemical Property of (2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoic acid

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Technology Process of (2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoic acid

There total 5 articles about (2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1370478-36-6
ethyl (2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoate

: 1370478-44-6
(2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1007/s00044-012-0020-3

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 1370478-44-6
(2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: neat (no solvent) / 2 h / 120 - 130 °C

2: diphenylether / 1 h / 260 °C

3: potassium carbonate / dimethyl sulfoxide / 8 h / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 15 h / 80 - 90 °C

5: lithium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

With water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; diphenylether; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1007/s00044-012-0020-3

Reference yield:

: 391-02-6
4-hydroxy-7-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester

: 1370478-44-6
(2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 8 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 15 h / 80 - 90 °C

3: lithium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

With water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1007/s00044-012-0020-3