ethyl (2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoate

Base Information

• Chemical Name: ethyl (2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoate
• CAS No.: 1370478-36-6
• Molecular Formula: C₂₄H₂₃F₃N₂O₄
• Molecular Weight: 460.453

Synonyms:ethyl (2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoate

Chemical Property of ethyl (2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoate

There total 3 articles about ethyl (2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(2R)-2-({[4-hydroxy-7-(trifluoromethyl)-3-quinolyl]carbonyl}amino)-3-phenylpropanoic acid (1370478-28-6) + ethyl iodide (75-03-6) → ethyl (2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoate (1370478-36-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 15h;

DOI:10.1007/s00044-012-0020-3

Reference yield:

3-trifluoromethylaniline (98-16-8) → ethyl (2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoate (1370478-36-6)

Guidance literature:

Multi-step reaction with 4 steps

1: neat (no solvent) / 2 h / 120 - 130 °C

2: diphenylether / 1 h / 260 °C

3: potassium carbonate / dimethyl sulfoxide / 8 h / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 15 h / 80 - 90 °C

With potassium carbonate; In diphenylether; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1007/s00044-012-0020-3

Reference yield:

diethyl 2-({[3-(trifluoromethyl)phenyl]amino}methylidene)propanedioate (370-35-4) → ethyl (2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoate (1370478-36-6)

Guidance literature:

Multi-step reaction with 3 steps

1: diphenylether / 1 h / 260 °C

2: potassium carbonate / dimethyl sulfoxide / 8 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 15 h / 80 - 90 °C

With potassium carbonate; In diphenylether; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1007/s00044-012-0020-3

upstream raw materials:

(2R)-2-({[4-hydroxy-7-(trifluoromethyl)-3-quinolyl]carbonyl}amino)-3-phenylpropanoic acid

ethyl iodide

3-trifluoromethylaniline

diethyl 2-({[3-(trifluoromethyl)phenyl]amino}methylidene)propanedioate

Downstream raw materials:

(2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1370478-36-6 ethyl (2R)-2-({[1-ethyl-4-oxo-7-(trifluoromethyl)-1,4-dihydro-3-quinolinyl]carbonyl}amino)-3-phenylpropanoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send