2,4,6-Trimethyl-benzenesulfonic acid 2-amino-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl ester

Base Information

Chemical Name:2,4,6-Trimethyl-benzenesulfonic acid 2-amino-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl ester
CAS No.:120853-25-0
Molecular Formula:C₃₇H₅₉N₅O₁₀SSi₂
Molecular Weight:822.14
Hs Code.:

2,4,6-Trimethyl-benzenesulfonic acid 2-amino-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl ester

Synonyms:2,4,6-Trimethyl-benzenesulfonic acid 2-amino-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl ester

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Chemical Property of 2,4,6-Trimethyl-benzenesulfonic acid 2-amino-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl ester

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Technology Process of 2,4,6-Trimethyl-benzenesulfonic acid 2-amino-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl ester

There total 5 articles about 2,4,6-Trimethyl-benzenesulfonic acid 2-amino-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 773-64-8
2-mesitylenesulphonyl chloride

: 120853-24-9
2'-O-(4-methoxytetrahydropyran-4-yl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

: 120853-25-0
2,4,6-Trimethyl-benzenesulfonic acid 2-amino-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1021/jo00274a041

Reference yield:

: 69304-44-5
3',5'-O-1,1,3,3-tetraisopropyldisiloxan-1,3-diyl-guanosine

: 120853-25-0
2,4,6-Trimethyl-benzenesulfonic acid 2-amino-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / dimethylformamide / 20 h / Ambient temperature

2: 2-mesitylenesulfonic acid / tetrahydrofuran / 3 h / Ambient temperature

3: methanol. NH₃ / CH₂Cl₂ / 24 h / Ambient temperature

4: 82 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; mesitylene sulfonic acid; ammonia; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00274a041

Reference yield:

: 17327-22-9
4-methoxy-2,6-dihydropyran

: 120853-25-0
2,4,6-Trimethyl-benzenesulfonic acid 2-amino-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2-mesitylenesulfonic acid / tetrahydrofuran / 3 h / Ambient temperature

2: methanol. NH₃ / CH₂Cl₂ / 24 h / Ambient temperature

3: 82 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; mesitylene sulfonic acid; ammonia; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00274a041