2-(2-phenylethyl)-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one

Base Information

• Chemical Name: 2-(2-phenylethyl)-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one
• CAS No.: 1417818-03-1
• Molecular Formula: C₁₇H₂₀N₂O₃
• Molecular Weight: 300.357
• Mol file: 1417818-03-1.mol

Synonyms:2-(2-phenylethyl)-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one

Chemical Property of 2-(2-phenylethyl)-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one

Chemical Property:

Purity/Quality:

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Technology Process of 2-(2-phenylethyl)-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one

There total 1 articles about 2-(2-phenylethyl)-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

ethyl (tetrahydropyranyloxy)acetate (61675-94-3) + 3-phenylpropionamidine (24442-03-3) + formic acid ethyl ester (109-94-4) → 2-(2-phenylethyl)-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one (1417818-03-1)

Guidance literature:

ethyl (tetrahydropyranyloxy)acetate; formic acid ethyl ester; With sodium hydride; In diethyl ether; mineral oil; for 2h; Reflux;

3-phenylpropionamidine; With trimethylaluminum; In tetrahydrofuran; mineral oil; for 4h; Reflux;

Reference yield: 11.0%

2-(2-phenylethyl)-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one (1417818-03-1) → 5-hydroxy-2-(2-phenylethyl)pyrimidin-4(3H)-one (1417817-39-0)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 20 - 25 ℃; for 3h;

upstream raw materials:

ethyl (tetrahydropyranyloxy)acetate

3-phenylpropionamidine

formic acid ethyl ester

Downstream raw materials:

5-hydroxy-2-(2-phenylethyl)pyrimidin-4(3H)-one