(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methanesulfonyl-butyric acid tert-butyl ester

Base Information

Chemical Name:(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methanesulfonyl-butyric acid tert-butyl ester
CAS No.:1027505-27-6
Molecular Formula:C₅₂H₆₈N₄O₈S₂
Molecular Weight:941.266
Hs Code.:

(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methanesulfonyl-butyric acid tert-butyl ester

Synonyms:(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methanesulfonyl-butyric acid tert-butyl ester

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Chemical Property of (S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methanesulfonyl-butyric acid tert-butyl ester

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Technology Process of (S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methanesulfonyl-butyric acid tert-butyl ester

There total 6 articles about (S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methanesulfonyl-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62965-10-0
(S)-N-carbobenzoxy-tert-butylleucine

: 1027505-27-6
(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methanesulfonyl-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 45 percent / N,N-diisopropylethylamine, Bop-Cl / CH₂Cl₂ / a) from 0 deg C to 5 deg C, 2 h, b) 5 deg C, 16 h

2: 100 percent / 1 N NaOH / methanol / 2 h / Ambient temperature

3: N,N-diisopropylethylamine, Bop / acetonitrile; dimethylformamide / 16 h / Ambient temperature

4: H₂, 1 N HCl / 10percent palladium hydroxide/C / tetrahydrofuran / 3 h

5: acetic acid, sodium cyanoborohydride / methanol / 2.25 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium hydroxide - carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950642a

Reference yield:

: 78183-55-8
(S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, methyl ester, hydrochloride

: 1027505-27-6
(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methanesulfonyl-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 45 percent / N,N-diisopropylethylamine, Bop-Cl / CH₂Cl₂ / a) from 0 deg C to 5 deg C, 2 h, b) 5 deg C, 16 h

2: 100 percent / 1 N NaOH / methanol / 2 h / Ambient temperature

3: N,N-diisopropylethylamine, Bop / acetonitrile; dimethylformamide / 16 h / Ambient temperature

4: H₂, 1 N HCl / 10percent palladium hydroxide/C / tetrahydrofuran / 3 h

5: acetic acid, sodium cyanoborohydride / methanol / 2.25 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium hydroxide - carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950642a

Reference yield:

: 166169-82-0
(S)-1,2,3,4-tetrahydro-2-<3-methyl-N-<(phenylmethoxy)-carbonyl>-L-valyl>-3-isoquinolinecarboxylic acid

: 1027505-27-6
(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methanesulfonyl-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-diisopropylethylamine, Bop / acetonitrile; dimethylformamide / 16 h / Ambient temperature

2: H₂, 1 N HCl / 10percent palladium hydroxide/C / tetrahydrofuran / 3 h

3: acetic acid, sodium cyanoborohydride / methanol / 2.25 h / Ambient temperature

With hydrogenchloride; hydrogen; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium hydroxide - carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950642a