(S)-2-AMINO-2-METHYL-BUTYRIC ACID METHYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: (S)-2-AMINO-2-METHYL-BUTYRIC ACID METHYL ESTER HYDROCHLORIDE
• CAS No.: 92760-72-0
• Molecular Formula: C6H13 N O2 . Cl H
• Molecular Weight: 167.636
• Hs Code.: 2922499990
• Mol file: 92760-72-0.mol

Synonyms:L-Isovaline,methyl ester, hydrochloride (9CI)

Chemical Property of (S)-2-AMINO-2-METHYL-BUTYRIC ACID METHYL ESTER HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.438mmHg at 25°C
• Boiling Point: 191.4 °C at 760 mmHg
• Flash Point: 69.5 °C
• PSA: 52.32000
• LogP: 1.78910
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

MethylD-IsovalineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-AMINO-2-METHYL-BUTYRIC ACID METHYL ESTER HYDROCHLORIDE

There total 4 articles about (S)-2-AMINO-2-METHYL-BUTYRIC ACID METHYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + L-isovaline (595-40-4,465-58-7) → L-isovalin methyl ester hydrochloride (92760-72-0)

Guidance literature:

With thionyl chloride; for 3h; Reflux;

Reference yield:

(S)-isovaline methyl ester hydrochloride [Methyl (S)-2-amino-2-methylbutanoate] + (2S)-2-amino-2-methylbutanoic acid hydrochloride (43177-22-6) → L-isovalin methyl ester hydrochloride (92760-72-0)

Guidance literature:

With thionyl chloride; sodium chloride; In methanol; toluene;

Reference yield:

(2R,4S)-3-Benzoyl-4-ethyl-4-methyl-2-phenyl-oxazolidin-5-one (118995-18-9,1279025-92-1) → L-isovalin methyl ester hydrochloride (92760-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. HCl / 3 h / Heating

2: SOCl₂ / Heating

With hydrogenchloride; thionyl chloride;

DOI:10.1016/S0040-4020(01)86182-2

upstream raw materials:

methanol

(2S)-2-amino-2-methylbutanoic acid hydrochloride

L-isovaline

(2R,4S)-3-Benzoyl-4-ethyl-4-methyl-2-phenyl-oxazolidin-5-one

Downstream raw materials:

(+)-S-zoxamide

Boc-Gly-L-Iva-L-Pro-Gca-pNA

Boc-Gly-L-Iva-L-Pro-Gly-pNA

(S)-1-[(S)-2-(2-Amino-acetylamino)-2-methyl-butyryl]-pyrrolidine-2-carboxylic acid [(4-nitro-phenylcarbamoyl)-methyl]-amide

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