(2S,4R)-3-BENZOYL-4-ETHYL-4-METHYL-2-PHENYL-OXAZOLIDIN-5-ONE

Base Information

• Chemical Name: (2S,4R)-3-BENZOYL-4-ETHYL-4-METHYL-2-PHENYL-OXAZOLIDIN-5-ONE
• CAS No.: 118995-18-9
• Molecular Formula: C19H19 N O3
• Molecular Weight: 309.365
• Mol file: 118995-18-9.mol

Synonyms:(2S,4R)-3-BENZOYL-4-ETHYL-4-METHYL-2-PHENYL-OXAZOLIDIN-5-ONE

Chemical Property of (2S,4R)-3-BENZOYL-4-ETHYL-4-METHYL-2-PHENYL-OXAZOLIDIN-5-ONE

Chemical Property:

• Vapor Pressure: 1.87E-10mmHg at 25°C
• Refractive Index: 1.573
• Boiling Point: 508.3°C at 760 mmHg
• Flash Point: 261.2°C
• PSA: 46.61000
• Density: 1.169g/cm³
• LogP: 3.49100

Purity/Quality:

97% ^*data from raw suppliers

(2S,4R)-3-BENZOYL-4-ETHYL-4-METHYL-2-PHENYL-OXAZOLIDIN-5-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S,4R)-3-BENZOYL-4-ETHYL-4-METHYL-2-PHENYL-OXAZOLIDIN-5-ONE

There total 2 articles about (2S,4R)-3-BENZOYL-4-ETHYL-4-METHYL-2-PHENYL-OXAZOLIDIN-5-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl iodide (75-03-6) + (+)-(2R,4S)-3-benzoyl-4-methyl-2-phenyl-1,3-oxazolidin-5-one (113806-28-3) → (2R,4S)-3-Benzoyl-4-ethyl-4-methyl-2-phenyl-oxazolidin-5-one (118995-18-9,1279025-92-1)

Guidance literature:

With lithium hexamethyldisilazane; Multistep reaction; 1.) THF, HMPA, -75 deg C 2.) THF, HMPA, -75 deg C, 3 h 3.) RT, overnight;

DOI:10.1016/S0040-4020(01)86182-2

Reference yield:

ethyl iodide (75-03-6) + (-)-(2S,4R)-3-benzoyl-4-methyl-2-phenyl-1,3-oxazolidin-5-one (118995-17-8) → (2S,4R)-3-benzoyl-4-ethyl-4-methyl-2-phenyl-1,3-oxazolidin-5-one (118995-18-9,1279025-92-1)

Guidance literature:

With lithium hexamethyldisilazane; Yield given. Multistep reaction; 1.) THF, HMPA, -75 deg C 2.) THF, HMPA, -75 deg C, 3 h 3.) RT, overnight; further reag: LDA;

DOI:10.1016/S0040-4020(01)86182-2

Reference yield:

(2S,4R)-3-benzoyl-4-ethyl-4-methyl-2-phenyl-1,3-oxazolidin-5-one (118995-18-9,1279025-92-1) → benzaldehyde (100-52-7) + (2R)-2-amino-2-methylbutanoic acid hydrochloride (73473-40-2) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

With hydrogenchloride; for 3h; Yield given; Heating;

DOI:10.1016/S0040-4020(01)86182-2

upstream raw materials:

ethyl iodide

(-)-(2S,4R)-3-benzoyl-4-methyl-2-phenyl-1,3-oxazolidin-5-one

(+)-(2R,4S)-3-benzoyl-4-methyl-2-phenyl-1,3-oxazolidin-5-one

Downstream raw materials:

benzaldehyde

(2R)-2-amino-2-methylbutanoic acid hydrochloride

benzoic acid

(R)-methyl 2-(amino)-2-methylbutanoate