1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-2-hydroxypropane

Base Information

Chemical Name:1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-2-hydroxypropane
CAS No.:253590-69-1
Molecular Formula:C₃₇H₅₆N₄O₇
Molecular Weight:668.874
Hs Code.:

Synonyms:1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-2-hydroxypropane

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Chemical Property of 1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-2-hydroxypropane

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Technology Process of 1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-2-hydroxypropane

There total 3 articles about 1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-2-hydroxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 13734-41-3
t-Boc-L-valine

: 65838-17-7
1,3-di-(N-benzylamino)-2-hydroxypropane

: 253590-69-1
1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-2-hydroxypropane

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/S0223-5234(00)80031-8

Reference yield:

: 100-52-7
benzaldehyde

: 253590-69-1
1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-2-hydroxypropane

Guidance literature:: Multi-step reaction with 3 steps

1: Na₂SO₄ / CH₂Cl₂ / 20 °C

2: NaBH₄ / ethanol / 20 °C

3: 95 percent / DCC; HOBT; Et₃N / dimethylformamide / 0 - 20 °C

With sodium tetrahydroborate; benzotriazol-1-ol; sodium sulfate; triethylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: Reduction / 3: Condensation;
DOI:10.1016/S0223-5234(00)80031-8

Reference yield:

: 1,3-bis[(E)-benzylideneamino]propan-2-ol

: 253590-69-1
1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-2-hydroxypropane

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄ / ethanol / 20 °C

2: 95 percent / DCC; HOBT; Et₃N / dimethylformamide / 0 - 20 °C

With sodium tetrahydroborate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In ethanol; N,N-dimethyl-formamide; 1: Reduction / 2: Condensation;
DOI:10.1016/S0223-5234(00)80031-8