α-vinyl-(4-fluoro-phenyl)methanol

Base Information

• Chemical Name: α-vinyl-(4-fluoro-phenyl)methanol
• CAS No.: 1282033-68-4
• Molecular Formula: C₉H₉FO
• Molecular Weight: 152.168
• Mol file: 1282033-68-4.mol

Synonyms:α-vinyl-(4-fluoro-phenyl)methanol

Chemical Property of α-vinyl-(4-fluoro-phenyl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-vinyl-(4-fluoro-phenyl)methanol

There total 4 articles about α-vinyl-(4-fluoro-phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

vinyl acetate (108-05-4,9003-20-7) + 1-(4-fluorophenyl)allyl alcohol (5724-03-8) → α-vinyl-(4-fluoro-phenyl)methanol (1282033-68-4) + (R)-(-)-1-acetoxy-1-(4-fluorophenyl)-2-propylene (1337953-60-2) + α-vinyl-(4-fluoro-phenyl)methanol (1339948-01-4)

Guidance literature:

With lipase PS-30; In toluene; at 20 ℃; for 50h; optical yield given as %ee; enantioselective reaction; Molecular sieve; Inert atmosphere; Enzymatic reaction;

DOI:10.1016/j.tetlet.2011.08.093

Reference yield:

1-(4-fluorophenyl)allyl alcohol (5724-03-8) + amoxapine (14028-44-5) → α-vinyl-(4-fluoro-phenyl)methanol (1282033-68-4) + α-vinyl-(4-fluoro-phenyl)methanol (1339948-01-4) + C26H25ClFN3O2 + C26H25ClFN3O2

Guidance literature:

With potassium tert-butylate; C₃₆H₄₀Cl₂N₂P₂Ru; In isopropyl alcohol; toluene; at 20 ℃; for 6h; Inert atmosphere;

Reference yield:

1-(4-fluorophenyl)allyl alcohol (5724-03-8) → α-vinyl-(4-fluoro-phenyl)methanol (1282033-68-4) + (1R,2R)-(4-fluorophenyl)-2,3-glycidol (1282033-75-3)

Guidance literature:

With Escherichia coli BL₂₁ harboring the plasmid pET₂₈a(+) encoding the styAB gene from Pseudomonas sp. LQ₂₆; for 16h; pH=6.5; optical yield given as %ee; enantioselective reaction; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1039/c0cc04360e

upstream raw materials:

1-(4-fluorophenyl)allyl alcohol

4-fluorobenzaldehyde

vinyl acetate

amoxapine

Refernces

• 1、 -. "Method for preparing chiral gamma-amino alcohol and chiral alpha-allyl alcohol by one-pot method". Paragraph 0047-0050; 0055; 0226-0236. . Retrieved 2020/12/15.
• 2、 Chen, Peiran,Xiang, Peng. "Kinetic resolution of allylic alcohols via stereoselective acylation catalyzed by lipase PS-30". experimental part. p. 5758 - 5760. Retrieved 2011/12/03.