78587-72-1

Basic information

• Product Name: methyl 2-(3-amino-4-hydroxyphenyl)acetate
• Synonyms: METHYL 2-(3-AMINO-4-HYDROXYPHENYL)ACETATE;3-Amino-4-hydroxyphenylacetic acid methyl ester, 2-Amino-4-(2-methoxy-2-oxoethyl)phenol;Methyl 3-amino-4-hydroxyphenylacetate 95%;Methyl3-amino-4-hydroxyphenylacetate95%;Methyl 2-(3-amino-4-hydroxyphenyl)
• CAS NO: 78587-72-1
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.19
• Mol File: 78587-72-1.mol

Chemical Properties

• Melting Point: 102-105°
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: methyl 2-(3-amino-4-hydroxyphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(3-amino-4-hydroxyphenyl)acetate(78587-72-1)
• EPA Substance Registry System: methyl 2-(3-amino-4-hydroxyphenyl)acetate(78587-72-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 78587-72-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2-(3-amino-4-hydroxyphenyl)acetate is used as a reagent for the preparation of benzoxazole derivatives, which are important in the synthesis of various pharmaceutical compounds. Benzoxazoles possess a wide range of biological activities, including antimicrobial, anti-inflammatory, and anticancer properties. The use of this ester in the synthesis process allows for the development of new drugs with improved therapeutic effects and reduced side effects.
Used in Chemical Synthesis:
In the field of chemical synthesis, methyl 2-(3-amino-4-hydroxyphenyl)acetate is utilized as a versatile building block for the creation of a variety of organic compounds. Its functional groups enable it to participate in numerous chemical reactions, such as condensation, substitution, and rearrangement reactions, leading to the formation of diverse chemical entities with potential applications in various industries.
Used in Research and Development:
Methyl 2-(3-amino-4-hydroxyphenyl)acetate is also employed in research and development settings, where it is used to explore new synthetic pathways and investigate the properties of novel compounds. Its unique structure and reactivity make it an attractive candidate for studying the mechanisms of various chemical reactions and for developing new methodologies in organic synthesis.

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 
• 34837-88-2 methyl 2-(4-methoxy-3-nitrophenyl)acetate 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 156-38-7 4-hydroxyphenylacetate 
• 10463-20-4 4-hydroxy-3-nitrophenylacetic acid 
• 61873-93-6 methyl (4-hydroxy-3-nitrophenyl)acetate 

Downstream Products

• 78597-73-6 [3-(4-Bromo-phenyl)-2-oxo-2H-benzo[1,4]oxazin-6-yl]-acetic acid methyl ester 
• 695186-52-8 methyl [3-(3-fluoro-4-nitro benzoylamino)-4-hydroxy-phenyl] acetate 
• 352210-79-8 methyl [3-(2,2-dimethylpropionamido)-4-hydroxyphenyl]acetate 
• 1422169-72-9 methyl 2-(3-(3,5-dimethylisoxazole-4-carboxamido)-4-hydroxyphenyl)acetate 
• 105213-19-2 {3-[(E)-2-(4-Chloro-phenyl)-vinyl]-2-oxo-2H-benzo[1,4]oxazin-6-yl}-acetic acid methyl ester 
• 78587-63-0 [3-(4-Fluoro-phenyl)-2-oxo-2H-benzo[1,4]oxazin-6-yl]-acetic acid methyl ester 
• 78587-64-1 (2-Oxo-3-p-tolyl-2H-benzo[1,4]oxazin-6-yl)-acetic acid methyl ester 
• 78587-62-9 [3-(4-Chloro-phenyl)-2-oxo-2H-benzo[1,4]oxazin-6-yl]-acetic acid methyl ester 
• 78587-61-8 (2-Oxo-3-phenyl-2H-benzo[1,4]oxazin-6-yl)-acetic acid methyl ester 
• 695187-48-5 methyl 2-(4-nitrophenyl)benzoxazole-5-acetate 
• 695187-49-6 methyl 2-(2-(4-aminophenyl)benzo[d]oxazol-5-yl)acetate 

Relevant articles and documents

N-{[2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYL}-2-(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXA ZIN-7-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AUTOIMMUNE DISEASES

The present invention provides e.g. N-{[2-(piperidin-1-yl)phenyl] (phenyl)methyl}-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)acetamide derivatives and related compounds as ROR-gamma modulators for treating e.g. autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases or cholestatic diseases, such as e.g. arthitis and asthma.

COMPOUNDS AND METHODS

The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORy.

SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS

The present invention relates to a series of substituted compounds having the general formula (I), including their ste reoisomers and/or their pharmaceutically acceptable salts, wherein R1, R2, R3. R4, R5, and R6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.

Efficient reducing system based on iron for conversion of nitroarenes to anilines

Reduction of nitroarenes with low solubility in EtOH-H2O to anilines easily occurs in a Fe-NH4Cl-acetone-H2O system, and treatment of the same nitroarenes with Fe-NH4Cl-EtOH-H2O hardly furnished the corresponding products. Under the reaction condition, the reducible or hydrolysable groups are not affected.

Synthetic route to a benzooxazole derivative with heparanase inhibitory activity

The synthesis of a benzooxazol-5-yl acetic acid derivative (9) with strong heparanase and angiogenesis inhibitory activity, and thus possible commercial interest, is described in detail. Copyright Taylor & Francis Group, LLC.

SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted aromatic carboxamide and urea derivatives, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions (formula (I)).

Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process for Making Them, and Use Thereof for Treating Pain and Other Conditions

Vanilloid receptor ligand compounds corresponding to formula I: pharmaceutical compositions containing such compounds, a process for producing such compounds, and methods of using such compounds for treating or inhibiting pain and various other disorders or conditions.

Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: Novel classes of heparanase inhibitor

Using a furanylthiazole acetic acid as a starting point, a novel series of benzoxazol-5-yl acetic acid derivatives have been identified as heparanase inhibitors. Several compounds possess an IC50 of ～200 nM against heparanase, for example, tran

PHARMACEUTICALLY ACTIVE BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE ACID DERIVATIVES

Compounds of formula (I): wherein R1, R2 and R3 are independently, hydrogen, halogen, CF3, OR6, NR7R8, NR8COR10, NR8SO2R10 or C1-6 alkyl optionally substituted by hydroxy, C1-6 alkoxy or NR7R8; R4 is NR8CONR8R9, NR8COR9, NR8SO2R9, or W-CONR8R9, where W is a bond, C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene; and R5 is Formula (A) methods for their synthesis, pharmaceutical compositions comprising them and their use in medicine, in particular for the treatment of cancer.

VLA-4 INHIBITORS

The present invention relates to a compound represented by the following formula (I): (wherein, W represents WA-A1 -WB - (in which, WA is substituted or unsubstituted aryl, etc., A1 is -NR1-, single bond, -C(O)-, etc., and WB is substituted or unsubstituted arylene, etc.), R is single bond, -NH-, -OCH2-, alkenylene, etc., X is -C(O) -CH2-, etc., and M is, for example, the following formula: (in which, R11, R12 and R13 each independently represents hydrogen, hydroxyl, amino, halogen, etc., R14 is hydrogen or lower alkyl, Y represents -CH2-O-, etc., Z is substituted or unsubstituted arylene, etc., A2 is single bond, etc, and R10 is hydroxyl or lower alkoxy)), or salt thereof; and a medicament containing the same. This compound or salt thereof selectively inhibits binding of cell adhesion molecules to VAL-4 and exhibits high bioavailability so that it is useful as a preventive and/or remedy for inflammatory diseases, autoimmune diseases, metastasis, bronchial asthma, rhinostenosis, diabetes, and the like.