(2R,4R,5S)-7-benzyloxy-5-hydroxy-2,4-dimethyl-3-oxo-heptanoic acid methoxy-methyl-amide

Base Information

• Chemical Name: (2R,4R,5S)-7-benzyloxy-5-hydroxy-2,4-dimethyl-3-oxo-heptanoic acid methoxy-methyl-amide
• CAS No.: 475232-93-0
• Molecular Formula: C₁₈H₂₇NO₅
• Molecular Weight: 337.416

Synonyms:(2R,4R,5S)-7-benzyloxy-5-hydroxy-2,4-dimethyl-3-oxo-heptanoic acid methoxy-methyl-amide

Chemical Property of (2R,4R,5S)-7-benzyloxy-5-hydroxy-2,4-dimethyl-3-oxo-heptanoic acid methoxy-methyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4R,5S)-7-benzyloxy-5-hydroxy-2,4-dimethyl-3-oxo-heptanoic acid methoxy-methyl-amide

There total 1 articles about (2R,4R,5S)-7-benzyloxy-5-hydroxy-2,4-dimethyl-3-oxo-heptanoic acid methoxy-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3-Benzyloxypropanal (19790-60-4) + methylketene dimer (476365-25-0) + N,0-dimethylhydroxylamine (1117-97-1) → (2R,4R,5S)-7-benzyloxy-5-hydroxy-2,4-dimethyl-3-oxo-heptanoic acid methoxy-methyl-amide (475232-93-0)

Guidance literature:

N,0-dimethylhydroxylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

methylketene dimer; In tetrahydrofuran; hexane; at -78 ℃;

3-Benzyloxypropanal; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h;

DOI:10.1016/S0040-4020(02)00723-8

Reference yield: 69.0%

(2R,4R,5S)-7-benzyloxy-5-hydroxy-2,4-dimethyl-3-oxo-heptanoic acid methoxy-methyl-amide (475232-93-0) → (2R,3R,4R,5S)-7-benzyloxy-3,5-dihydroxy-2,4-dimethylheptanoic acid methoxy-methyl-amide (475232-94-1)

Guidance literature:

With sodium tris(acetoxy)borohydride; In acetic acid; at 20 ℃; for 0.75h;

DOI:10.1016/S0040-4020(02)00723-8

Reference yield:

(2R,4R,5S)-7-benzyloxy-5-hydroxy-2,4-dimethyl-3-oxo-heptanoic acid methoxy-methyl-amide (475232-93-0) → [2R(4R,5R,6S)]-2-[6-(2-benzyloxyethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-N-methoxy-N-methylpropionamide (475232-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / NaBH(OAc)3 / acetic acid / 0.75 h / 20 °C

2: 86 percent / p-toluenesulfonic acid / acetone / 0.5 h / 20 °C

With sodium tris(acetoxy)borohydride; toluene-4-sulfonic acid; In acetic acid; acetone;

DOI:10.1016/S0040-4020(02)00723-8

upstream raw materials:

3-Benzyloxypropanal

methylketene dimer

N,0-dimethylhydroxylamine

Downstream raw materials:

(2R,3R,4R,5S)-7-benzyloxy-3,5-dihydroxy-2,4-dimethylheptanoic acid methoxy-methyl-amide

(R)-2-[(4R,5R,6S)-6-(2-Benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-propionaldehyde

[2S(4S,5R,6S)]-2-[6-(2-benzyloxyethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]propan-1-ol

[4S,5R,6R(1R)]-4-(2-benzyloxyethyl)-6-(2-iodo-1-methylethyl)-2,2,5-trimethyl-[1,3]dioxane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 475232-93-0 (2R,4R,5S)-7-benzyloxy-5-hydroxy-2,4-dimethyl-3-oxo-heptanoic acid methoxy-methyl-amide

Send

Send

Metric Ton KG G Pound L ML

Send

Send