N,N',N'',N'''-[(2,2'-ethyne-2,1-diyl)diterephthaloyl](L,L,L,L)tetra-leucine methyl ester

Base Information

Chemical Name:N,N',N'',N'''-[(2,2'-ethyne-2,1-diyl)diterephthaloyl](L,L,L,L)tetra-leucine methyl ester
CAS No.:1349009-12-6
Molecular Formula:C₄₆H₆₂N₄O₁₂
Molecular Weight:863.018
Hs Code.:

Synonyms:N,N',N'',N'''-[(2,2'-ethyne-2,1-diyl)diterephthaloyl](L,L,L,L)tetra-leucine methyl ester

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Chemical Property of N,N',N'',N'''-[(2,2'-ethyne-2,1-diyl)diterephthaloyl](L,L,L,L)tetra-leucine methyl ester

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Technology Process of N,N',N'',N'''-[(2,2'-ethyne-2,1-diyl)diterephthaloyl](L,L,L,L)tetra-leucine methyl ester

There total 3 articles about N,N',N'',N'''-[(2,2'-ethyne-2,1-diyl)diterephthaloyl](L,L,L,L)tetra-leucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1417436-41-9
N,N'-[2-bromoterephthaloyl](L,L)di-leucine methyl ester

: 994-71-8
bis(tributylstannyl)acetylene

: 1349009-12-6
N,N',N'',N'''-[(2,2'-ethyne-2,1-diyl)diterephthaloyl](L,L,L,L)tetra-leucine methyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 110 ℃; Schlenk technique; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.11.034

Reference yield:

: 586-35-6
2-bromo-1,4-benzenedicarboxylic acid

: 1349009-12-6
N,N',N'',N'''-[(2,2'-ethyne-2,1-diyl)diterephthaloyl](L,L,L,L)tetra-leucine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride

2: pyridine / dichloromethane / 20 °C / Schlenk technique; Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 110 °C / Schlenk technique; Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; In 1,4-dioxane; dichloromethane; 3: |Stille Cross Coupling;
DOI:10.1016/j.tetlet.2012.11.034

Reference yield:

: 13815-89-9
2-bromobenzene-1,4-dicarbonyl dichloride

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 1349009-12-6
N,N',N'',N'''-[(2,2'-ethyne-2,1-diyl)diterephthaloyl](L,L,L,L)tetra-leucine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 20 °C / Schlenk technique; Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 110 °C / Schlenk technique; Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; 2: |Stille Cross Coupling;
DOI:10.1016/j.tetlet.2012.11.034