(S)-4-Methyl-2-[methyl-(3-methyl-but-2-enyl)-amino]-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride

Base Information

Chemical Name:(S)-4-Methyl-2-[methyl-(3-methyl-but-2-enyl)-amino]-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride
CAS No.:248921-71-3
Molecular Formula:C₂₈H₃₈F₂N₂O*ClH
Molecular Weight:493.08
Hs Code.:

Synonyms:(S)-4-Methyl-2-[methyl-(3-methyl-but-2-enyl)-amino]-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride

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Chemical Property of (S)-4-Methyl-2-[methyl-(3-methyl-but-2-enyl)-amino]-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride

Chemical Property:

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Technology Process of (S)-4-Methyl-2-[methyl-(3-methyl-but-2-enyl)-amino]-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride

There total 4 articles about (S)-4-Methyl-2-[methyl-(3-methyl-but-2-enyl)-amino]-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethereal HCl: ethereal HCl

: 248921-70-2
(S)-4-Methyl-2-methylamino-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride

: 107-86-8
3,3-dimethyl acrylaldehyde

: 144-55-8
sodium hydrogencarbonate

: 248921-71-3
(S)-4-Methyl-2-[methyl-(3-methyl-but-2-enyl)-amino]-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride

Guidance literature:: With sodium tris(acetoxy)borohydride; In diethyl ether; dichloromethane; chloroform; ethyl acetate; acetonitrile;

Reference yield:

: 53363-89-6
N-t-butoxycarbonyl-N-methyl-L-leucine

: 248921-71-3
(S)-4-Methyl-2-[methyl-(3-methyl-but-2-enyl)-amino]-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / diethyl ether; N,N-dimethyl-formamide

2: hydrogenchloride; trifluoroacetic acid / methanol; diethyl ether; dichloromethane; chloroform

3: sodium tris(acetoxy)borohydride / diethyl ether; dichloromethane; chloroform; ethyl acetate; acetonitrile

With hydrogenchloride; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 248922-88-5
(S)-{1-[4,4-bis-(4-fluoro-phenyl)-butylcarbamoyl]-3-methyl-butyl}-methyl-carbamic acid tert-butyl ester

: 248921-71-3
(S)-4-Methyl-2-[methyl-(3-methyl-but-2-enyl)-amino]-pentanoic acid [4,4-bis-(4-fluoro-phenyl)-butyl]-amide monohydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; trifluoroacetic acid / methanol; diethyl ether; dichloromethane; chloroform

2: sodium tris(acetoxy)borohydride / diethyl ether; dichloromethane; chloroform; ethyl acetate; acetonitrile

With hydrogenchloride; sodium tris(acetoxy)borohydride; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; chloroform; ethyl acetate; acetonitrile;