(R)-N-METHOXY-N-METHYL-1-((S)-1-PHENYLETHYL)AZIRIDINE-2-CARBOXAMIDE

Base Information

• Chemical Name: (R)-N-METHOXY-N-METHYL-1-((S)-1-PHENYLETHYL)AZIRIDINE-2-CARBOXAMIDE
• CAS No.: 853056-96-9
• Molecular Formula: C13H18 N2 O2
• Molecular Weight: 234.298
• Mol file: 853056-96-9.mol

Synonyms:(R)-N-METHOXY-N-METHYL-1-((S)-1-PHENYLETHYL)AZIRIDINE-2-CARBOXAMIDE

Chemical Property of (R)-N-METHOXY-N-METHYL-1-((S)-1-PHENYLETHYL)AZIRIDINE-2-CARBOXAMIDE

Chemical Property:

• Boiling Point: 299.1 °C at 760 mmHg
• Flash Point: 134.7 °C
• PSA: 32.55000
• Density: 1.164 g/cm³
• LogP: 1.38950
• Water Solubility.: at 25 deg C (mg/L): 2257

Purity/Quality:

(R)-N-METHOXY-N-METHYL-1-((S)-1-PHENYLETHYL)AZIRIDINE-2-CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-N-METHOXY-N-METHYL-1-((S)-1-PHENYLETHYL)AZIRIDINE-2-CARBOXAMIDE

There total 6 articles about (R)-N-METHOXY-N-METHYL-1-((S)-1-PHENYLETHYL)AZIRIDINE-2-CARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + (2S)-1-[(R)-α-methylbenzyl]-2-aziridinecarboxylate ethyl ester (68820-72-4) → N-[(R)-α-methylbenzyl]-(2S)-aziridine-(N'-methoxy-N'-methyl)carboxamide (853056-96-9)

Guidance literature:

With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c0ob00730g

Reference yield: 95.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + N-[(R)-(+)-α-methylbenzyl]-2(S)-carboxylic acid (-)-menthol ester (397849-98-8,397849-97-7) → N-[(R)-α-methylbenzyl]-(2S)-aziridine-(N'-methoxy-N'-methyl)carboxamide (853056-96-9)

Guidance literature:

With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.04.069

Reference yield: 94.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + N-[(R)-(+)-α-methylbenzyl]aziridine-2-(S)-carboxylic acid menthyl ester (397849-98-8,397849-97-7) → N-[(R)-α-methylbenzyl]-(2S)-aziridine-(N'-methoxy-N'-methyl)carboxamide (853056-96-9)

Guidance literature:

With isopropylmagnesium chloride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2005.02.053

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

N-[(R)-(+)-α-methylbenzyl]aziridine-2-(S)-carboxylic acid menthyl ester

N,0-dimethylhydroxylamine

N-[(R)-(+)-α-methylbenzyl]-2(S)-carboxylic acid (-)-menthol ester

Downstream raw materials:

1-{(S)-1-[(R)-1-phenylethyl]aziridin-2-yl}hexadec-2-yn-1-one

2-phenyl-1-((S)-1-((R)-1-phenylethyl)aziridine-2-yl)ethanone

(2S)-N-[(R)-α-methylbenzyl]aziridinyl phenyl ketone

4-(tert-butyldimethylsilyloxy)-1-{(S)-1-[(R)-1-phenylethyl]aziridin-2-yl}butan-1-one