(Z)-tert-butyl N-(4-amino-3,5-dichlorobenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisoxazole-4-carbonyl)carbamimidoylcarbamate

Base Information

Chemical Name:(Z)-tert-butyl N-(4-amino-3,5-dichlorobenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisoxazole-4-carbonyl)carbamimidoylcarbamate
CAS No.:917475-47-9
Molecular Formula:C₂₅H₂₇Cl₂N₅O₅
Molecular Weight:548.426
Hs Code.:

Synonyms:(Z)-tert-butyl N-(4-amino-3,5-dichlorobenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisoxazole-4-carbonyl)carbamimidoylcarbamate

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Chemical Property of (Z)-tert-butyl N-(4-amino-3,5-dichlorobenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisoxazole-4-carbonyl)carbamimidoylcarbamate

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Technology Process of (Z)-tert-butyl N-(4-amino-3,5-dichlorobenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisoxazole-4-carbonyl)carbamimidoylcarbamate

There total 4 articles about (Z)-tert-butyl N-(4-amino-3,5-dichlorobenzyl)-N'-(3-(4-methoxyphenyl)-5-methylisoxazole-4-carbonyl)carbamimidoylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 164648-75-3
4-(aminomethyl)-2,6-dichloroaniline

: 917388-78-4
tert-butyl N-(3-(4-methoxyphenyl)-5-methylisoxazole-4-carbonyl)(methylthio)carbonoimidoylcarbamate

: 1402164-85-5,917475-47-9
N-((4-amino-3,5-dichlorobenzylamino)(tert-butoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm300931y

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1402164-85-5,917475-47-9
N-((4-amino-3,5-dichlorobenzylamino)(tert-butoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / dichloromethane; water / 6 h / 0 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; water;
DOI:10.1021/jm300931y

Reference yield:

: 173998-77-1
N-(tert-butyloxycarbonyl)-S-methylisothiourea

: 1402164-85-5,917475-47-9
N-((4-amino-3,5-dichlorobenzylamino)(tert-butoxycarbonylamino)methylene)-3-(4-methoxyphenyl)-5-methylisoxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jm300931y