Technology Process of 2-(1-benzenesulfonyl-piperidin-3-yl)-N-methyl-N-piperidin-1-yl-acetamide
There total 10 articles about 2-(1-benzenesulfonyl-piperidin-3-yl)-N-methyl-N-piperidin-1-yl-acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(1-benzenesulfonyl-piperidin-3-yl)-N-piperidin-1-yl-acetamide;
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.333333h;
methyl iodide;
In
tetrahydrofuran;
at 0 ℃;
for 0.0833333h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium carbonate / water / 0.17 h / 0 °C
1.2: 0 - 20 °C
1.3: 0.25 - 0.5 h / 0 - 5 °C / pH 3
2.1: thionyl chloride / 0 - 20 °C / Heating / reflux
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
3.2: 0 °C
4.1: triethylamine / dichloromethane / 0.17 - 0.33 h / 0 - 5 °C
4.2: 0 - 20 °C
5.1: 18-crown-6 ether / N,N-dimethyl-formamide / 14 - 16 h / 60 °C
6.1: hydrogenchloride
7.1: potassium hydroxide; water / methanol / 16 - 18 h / 20 °C
7.2: 0 - 5 °C
8.1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 16 h / 0 - 20 °C
9.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C
9.2: 0.08 h / 0 °C
With
hydrogenchloride; dmap; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; 18-crown-6 ether; water; sodium hydride; sodium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: thionyl chloride / 0 - 20 °C / Heating / reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2.2: 0 °C
3.1: triethylamine / dichloromethane / 0.17 - 0.33 h / 0 - 5 °C
3.2: 0 - 20 °C
4.1: 18-crown-6 ether / N,N-dimethyl-formamide / 14 - 16 h / 60 °C
5.1: hydrogenchloride
6.1: potassium hydroxide; water / methanol / 16 - 18 h / 20 °C
6.2: 0 - 5 °C
7.1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 16 h / 0 - 20 °C
8.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C
8.2: 0.08 h / 0 °C
With
hydrogenchloride; dmap; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; 18-crown-6 ether; water; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
