7-chloro-2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Base Information

Chemical Name:7-chloro-2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine
CAS No.:174311-48-9
Molecular Formula:C₁₈H₁₈Cl₂N₂
Molecular Weight:333.26
Hs Code.:

Synonyms:7-chloro-2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

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Chemical Property of 7-chloro-2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

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Technology Process of 7-chloro-2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

There total 1 articles about 7-chloro-2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 151255-31-1
7-chloro-2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

: 174311-48-9
7-chloro-2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Guidance literature:: With thionyl chloride; In dichloromethane; for 4h; Yield given; Ambient temperature;
DOI:10.1021/jm950423p

Reference yield: 83.0%

: 1074-82-4
potassium phtalimide

: 174311-48-9
7-chloro-2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

: 174311-50-3
7-chloro-2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Guidance literature:: With potassium iodide; In N,N-dimethyl-formamide; at 70 ℃; for 20h;
DOI:10.1021/jm950423p

Reference yield:

: 174311-48-9
7-chloro-2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

: 1H-Indole-2-carboxylic acid [2-(7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / KI / dimethylformamide / 20 h / 70 °C

2: 85 percent / 98percent NH₂NH₂ / methanol / 4 h / Ambient temperature

3: 62 percent / Et₃N / tetrahydrofuran / 23 °C

With hydrazine hydrate; triethylamine; potassium iodide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950423p