7-chloro-2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Base Information

Chemical Name:7-chloro-2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine
CAS No.:151255-31-1
Molecular Formula:C₁₈H₁₉ClN₂O
Molecular Weight:314.815
Hs Code.:

Synonyms:7-chloro-2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

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Chemical Property of 7-chloro-2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

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Technology Process of 7-chloro-2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

There total 4 articles about 7-chloro-2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 151255-30-0
7-chloro-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2-acetic acid ethyl ester

: 151255-31-1
7-chloro-2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 0.25h;

Reference yield:

: 7-chloro-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-5-phenyl-1H-1,4-benzodiazepine

: 151255-31-1
7-chloro-2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / aq. NaOH, tetrabutylammonium bromide / benzene / 1.5 h / Heating

2: 80 percent / triethylsilane / trifluoroacetic acid / 0 °C

3: 85 percent / LiAlH₄ / diethyl ether / 0.25 h

With triethylsilane; sodium hydroxide; lithium aluminium tetrahydride; tetrabutylammomium bromide; In diethyl ether; trifluoroacetic acid; benzene;

Reference yield:

: 7-chloro-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-5-phenyl-1H-1,4-benzodiazepine-4-oxide

: 151255-31-1
7-chloro-2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / PCl₃ / CHCl₃ / 0.75 h / Heating

2: 76 percent / aq. NaOH, tetrabutylammonium bromide / benzene / 1.5 h / Heating

3: 80 percent / triethylsilane / trifluoroacetic acid / 0 °C

4: 85 percent / LiAlH₄ / diethyl ether / 0.25 h

With triethylsilane; sodium hydroxide; lithium aluminium tetrahydride; tetrabutylammomium bromide; phosphorus trichloride; In diethyl ether; chloroform; trifluoroacetic acid; benzene;