7-chloro-2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Base Information

Chemical Name:7-chloro-2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine
CAS No.:174311-52-5
Molecular Formula:C₁₈H₂₀ClN₃
Molecular Weight:313.83
Hs Code.:

Synonyms:7-chloro-2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

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Chemical Property of 7-chloro-2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

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Technology Process of 7-chloro-2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

There total 3 articles about 7-chloro-2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 174311-50-3
7-chloro-2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

: 174311-52-5
7-chloro-2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Guidance literature:: With hydrazine hydrate; In methanol; for 4h; Ambient temperature;
DOI:10.1021/jm950423p

Reference yield:

: 151255-31-1
7-chloro-2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

: 174311-52-5
7-chloro-2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CH₂Cl₂ / 4 h / Ambient temperature

2: 83 percent / KI / dimethylformamide / 20 h / 70 °C

3: 85 percent / 98percent NH₂NH₂ / methanol / 4 h / Ambient temperature

With thionyl chloride; hydrazine hydrate; potassium iodide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950423p

Reference yield:

: 174311-48-9
7-chloro-2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

: 174311-52-5
7-chloro-2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / KI / dimethylformamide / 20 h / 70 °C

2: 85 percent / 98percent NH₂NH₂ / methanol / 4 h / Ambient temperature

With hydrazine hydrate; potassium iodide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950423p