7-chloro-2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Base Information

• Chemical Name: 7-chloro-2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine
• CAS No.: 174311-50-3
• Molecular Formula: C₂₆H₂₂ClN₃O₂
• Molecular Weight: 443.933

Synonyms:7-chloro-2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Chemical Property of 7-chloro-2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Chemical Property:

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Technology Process of 7-chloro-2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

There total 2 articles about 7-chloro-2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

potassium phtalimide (1074-82-4) + 7-chloro-2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-48-9) → 7-chloro-2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-50-3)

Guidance literature:

With potassium iodide; In N,N-dimethyl-formamide; at 70 ℃; for 20h;

DOI:10.1021/jm950423p

Reference yield:

7-chloro-2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (151255-31-1) → 7-chloro-2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-50-3)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂ / 4 h / Ambient temperature

2: 83 percent / KI / dimethylformamide / 20 h / 70 °C

With thionyl chloride; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm950423p

Reference yield: 85.0%

7-chloro-2,3-dihydro-2-(2-phthalimidoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-50-3) → 7-chloro-2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-52-5)

Guidance literature:

With hydrazine hydrate; In methanol; for 4h; Ambient temperature;

DOI:10.1021/jm950423p

upstream raw materials:

potassium phtalimide

7-chloro-2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

7-chloro-2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Downstream raw materials:

7-chloro-2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

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