2-(2-(2-(5-methyl-2-((4-(piperidin-4-yloxy)phenyl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide

Base Information

Chemical Name:2-(2-(2-(5-methyl-2-((4-(piperidin-4-yloxy)phenyl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide
CAS No.:1566584-08-4
Molecular Formula:C₂₆H₃₁N₅O₂
Molecular Weight:445.564
Hs Code.:

Synonyms:2-(2-(2-(5-methyl-2-((4-(piperidin-4-yloxy)phenyl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide

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Chemical Property of 2-(2-(2-(5-methyl-2-((4-(piperidin-4-yloxy)phenyl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide

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Technology Process of 2-(2-(2-(5-methyl-2-((4-(piperidin-4-yloxy)phenyl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide

There total 10 articles about 2-(2-(2-(5-methyl-2-((4-(piperidin-4-yloxy)phenyl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1566585-23-6
tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-methylpyrimidin-2-yl)amino)phenoxy)piperidine-1-carboxylate

: 1566584-08-4
2-(2-(2-(5-methyl-2-((4-(piperidin-4-yloxy)phenyl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; water; at 6 - 20 ℃; for 4h;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1566584-08-4
2-(2-(2-(5-methyl-2-((4-(piperidin-4-yloxy)phenyl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol / 4 h / 0 - 20 °C

2: potassium tert-butylate / dimethyl sulfoxide / 2 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol

4: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 0.75 h / 100 °C / Microwave irradiation

5: trifluoroacetic acid / water; dichloromethane / 4 h / 6 - 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1566584-08-4
2-(2-(2-(5-methyl-2-((4-(piperidin-4-yloxy)phenyl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / dimethyl sulfoxide / 2 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol

3: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 0.75 h / 100 °C / Microwave irradiation

4: trifluoroacetic acid / water; dichloromethane / 4 h / 6 - 20 °C

With palladium 10% on activated carbon; potassium tert-butylate; hydrogen; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide;