5-Bromo-2-(2-thienyl)pyridine

Base Information

• Chemical Name: 5-Bromo-2-(2-thienyl)pyridine
• CAS No.: 91891-74-6
• Molecular Formula: C9H6 Br N S
• Molecular Weight: 240.123
• European Community (EC) Number: 678-981-5
• DSSTox Substance ID: DTXSID40531126
• Nikkaji Number: J2.333.968D
• Wikidata: Q82402740
• Mol file: 91891-74-6.mol

Synonyms:91891-74-6;5-bromo-2-(2-thienyl)pyridine;5-BROMO-2-(THIOPHEN-2-YL)PYRIDINE;5-BROMO-2-(THIEN-2-YL)PYRIDINE;5-bromo-2-thiophen-2-ylpyridine;SCHEMBL9967122;DTXSID40531126;2-(5-Bromo-2-pyridyl)thiophene;MFCD09037419;AKOS015945231;5-Bromo-2-(2-thienyl)pyridine,95%;BS-48966;B4885;CS-0330317;T71457;A916314

Chemical Property of 5-Bromo-2-(2-thienyl)pyridine

Chemical Property:

• Vapor Pressure: 0.00136mmHg at 25°C
• Melting Point: 79.0 to 83.0 °C
• Boiling Point: 306.8°Cat760mmHg
• Flash Point: 139.4°C
• PSA: 41.13000
• Density: 1.563g/cm³
• LogP: 3.57260
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 238.94043
• Heavy Atom Count: 12
• Complexity: 154

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2-(thien-2-yl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1)C2=NC=C(C=C2)Br

Technology Process of 5-Bromo-2-(2-thienyl)pyridine

There total 3 articles about 5-Bromo-2-(2-thienyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,5-dibromopyridine (624-28-2) + thiophen-2-yl magnesium bromide (5713-61-1) → 5-bromo-2-(thiophen-2-yl)pyridine (91891-74-6)

Guidance literature:

[1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride; for 5h; Ambient temperature;

DOI:10.1039/c39840000511

Reference yield:

5-bromo-2-iodopyrimidine (183438-24-6) + 5-bromo-2-(5-bromothiophen-2-yl)pyridine (136902-53-9) → 5-bromopyrimidine (4595-59-9) + 5-bromo-2-(thiophen-2-yl)pyridine (91891-74-6)

Guidance literature:

5-bromo-2-iodopyrimidine; 5-bromo-2-(5-bromothiophen-2-yl)pyridine; With isopropylmagnesium chloride; In tetrahydrofuran;

Hydrolysis;

DOI:10.1246/cl.2011.992

Reference yield:

thiophene boronic acid (6165-68-0) + 2-iodo-5-bromopyridine (223463-13-6) → 5-bromo-2-(thiophen-2-yl)pyridine (91891-74-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; toluene; at 120 ℃; for 18h;

upstream raw materials:

2,5-dibromopyridine

thiophen-2-yl magnesium bromide

5-bromo-2-iodopyrimidine

5-bromo-2-(5-bromothiophen-2-yl)pyridine

Downstream raw materials:

5-bromo-2-(5-bromothiophen-2-yl)pyridine

6,6'-bis(2''-thienyl)-3,3'-bipyridine

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