(2R,4S,5S)-2-(aminomethyl)-5-(dimethylamino)-4-(4-nitrophenyl)-1,3-dioxane

Base Information

• Chemical Name: (2R,4S,5S)-2-(aminomethyl)-5-(dimethylamino)-4-(4-nitrophenyl)-1,3-dioxane
• CAS No.: 1015693-20-5
• Molecular Formula: C₁₃H₁₉N₃O₄
• Molecular Weight: 281.312

Synonyms:(2R,4S,5S)-2-(aminomethyl)-5-(dimethylamino)-4-(4-nitrophenyl)-1,3-dioxane

Chemical Property of (2R,4S,5S)-2-(aminomethyl)-5-(dimethylamino)-4-(4-nitrophenyl)-1,3-dioxane

Chemical Property:

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Technology Process of (2R,4S,5S)-2-(aminomethyl)-5-(dimethylamino)-4-(4-nitrophenyl)-1,3-dioxane

There total 3 articles about (2R,4S,5S)-2-(aminomethyl)-5-(dimethylamino)-4-(4-nitrophenyl)-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(1S,2S)-2-(dimethylamino)1-(4-nitrophenyl)propane-1,3-diol hydrochloride + 2,2-diethoxy-ethanamine (645-36-3) → (2R,4S,5S)-2-(aminomethyl)-5-(dimethylamino)-4-(4-nitrophenyl)-1,3-dioxane (1015693-20-5)

Guidance literature:

With sulfuric acid; at 0 - 20 ℃; for 24h; diastereoselective reaction;

DOI:10.1002/ejoc.200700847

Reference yield:

threo-(1S,2S)-2-(dimethylamino)-1-(4-nitrophenyl)-1,3-propanediol (18867-44-2) + 2,2-diethoxy-ethanamine (645-36-3) → (2R,4S,5S)-2-(aminomethyl)-5-(dimethylamino)-4-(4-nitrophenyl)-1,3-dioxane (1015693-20-5)

Guidance literature:

threo-(1S,2S)-2-(dimethylamino)-1-(4-nitrophenyl)-1,3-propanediol; With sulfuric acid; at 0 ℃;

2,2-diethoxy-ethanamine; at 0 - 20 ℃; for 24h;

With ammonium hydroxide; In water; at 0 ℃; pH=9;

DOI:10.2478/s11532-012-0015-4

Reference yield:

threo-(1S,2S)-2-(dimethylamino)-1-(4-nitrophenyl)-1,3-propanediol (18867-44-2) + 2,2-dimethoxyethylamine (22483-09-6) → (2R,4S,5S)-2-(aminomethyl)-5-(dimethylamino)-4-(4-nitrophenyl)-1,3-dioxane (1015693-20-5)

Guidance literature:

threo-(1S,2S)-2-(dimethylamino)-1-(4-nitrophenyl)-1,3-propanediol; With sulfuric acid; at 0 ℃;

2,2-dimethoxyethylamine; at 0 - 20 ℃; for 24h;

With ammonium hydroxide; In water; at 0 ℃; pH=9;

DOI:10.2478/s11532-012-0015-4

upstream raw materials:

threo-(1S,2S)-2-(dimethylamino)-1-(4-nitrophenyl)-1,3-propanediol

2,2-diethoxy-ethanamine

2,2-dimethoxyethylamine

Downstream raw materials:

2,4-dichloro-6-{[(2R,4S,5S)-5-(dimethylamino)-4-(4-nitrophenyl)-1,3-dioxan-2-yl]methylamino}-s-triazine

2-chloro-4,6-bis[(2R,4S,5S)-{2-[(2,4-dichloro-s-triazin-6-yl)aminomethyl]-4-(4-nitrophenyl)-1,3-dioxan-5-yl}(methyl)amino]-s-triazine

2-chloro-4,6-bis{[(2R,4S,5S)-5-(dimethylamino)-4-(4-nitrophenyl)-1,3-dioxan-2-yl]methylamino}-s-triazine

2,4,6-tris{[(2R,4S,5S)-5-(dimethylamino)-4-(4-nitrophenyl)1,3-dioxan-2-yl]methylamino}-s-triazine

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