(S)-N-((tert-butyldimethylsilyl)(phenyl)methyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:(S)-N-((tert-butyldimethylsilyl)(phenyl)methyl)-4-methylbenzenesulfonamide
CAS No.:1586870-03-2
Molecular Formula:C₂₀H₂₉NO₂SSi
Molecular Weight:375.607
Hs Code.:

Synonyms:(S)-N-((tert-butyldimethylsilyl)(phenyl)methyl)-4-methylbenzenesulfonamide

Suppliers and Price of (S)-N-((tert-butyldimethylsilyl)(phenyl)methyl)-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-((tert-butyldimethylsilyl)(phenyl)methyl)-4-methylbenzenesulfonamide

Chemical Property:

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Technology Process of (S)-N-((tert-butyldimethylsilyl)(phenyl)methyl)-4-methylbenzenesulfonamide

There total 7 articles about (S)-N-((tert-butyldimethylsilyl)(phenyl)methyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: (E)-N-((tert-butyldimethylsilyl)(phenyl)methylene)-4-methylbenzenesulfonamide

: 1586870-03-2
(S)-N-((tert-butyldimethylsilyl)(phenyl)methyl)-4-methylbenzenesulfonamide

Guidance literature:: With (R,R)-(?)-2,3-bis(t-butylmethylphosphino)quinoxaline; palladium(II) trifluoroacetate; hydrogen; In 2,2,2-trifluoroethanol; acetone; at 20 ℃; for 10h; under 30402 Torr; enantioselective reaction; Schlenk technique; Autoclave;
DOI:10.1021/acs.orglett.8b04073

Reference yield:

: 461051-83-2
2-phenyl-2-(tert-butyl dimethylsilyl)-1,3-dithiane

: 1586870-03-2
(S)-N-((tert-butyldimethylsilyl)(phenyl)methyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; iodine / acetonitrile / Inert atmosphere

2: titanium tetrachloride; triethylamine / dichloromethane / Inert atmosphere

3: palladium(II) trifluoroacetate; (R,R)-(?)-2,3-bis(t-butylmethylphosphino)quinoxaline; hydrogen / acetone; 2,2,2-trifluoroethanol / 10 h / 20 °C / 30402 Torr / Schlenk technique; Autoclave

With (R,R)-(?)-2,3-bis(t-butylmethylphosphino)quinoxaline; palladium(II) trifluoroacetate; hydrogen; iodine; titanium tetrachloride; sodium hydrogencarbonate; triethylamine; In dichloromethane; 2,2,2-trifluoroethanol; acetone; acetonitrile;
DOI:10.1021/acs.orglett.8b04073

Reference yield:

: 5425-44-5
2-Phenyl-[1,3]dithiane

: 1586870-03-2
(S)-N-((tert-butyldimethylsilyl)(phenyl)methyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / Inert atmosphere

1.2: Inert atmosphere

2.1: sodium hydrogencarbonate; iodine / acetonitrile / Inert atmosphere

3.1: titanium tetrachloride; triethylamine / dichloromethane / Inert atmosphere

4.1: palladium(II) trifluoroacetate; (R,R)-(?)-2,3-bis(t-butylmethylphosphino)quinoxaline; hydrogen / acetone; 2,2,2-trifluoroethanol / 10 h / 20 °C / 30402 Torr / Schlenk technique; Autoclave

With (R,R)-(?)-2,3-bis(t-butylmethylphosphino)quinoxaline; n-butyllithium; palladium(II) trifluoroacetate; hydrogen; iodine; titanium tetrachloride; sodium hydrogencarbonate; triethylamine; In dichloromethane; 2,2,2-trifluoroethanol; acetone; acetonitrile;
DOI:10.1021/acs.orglett.8b04073