1,4-bis(4-methoxyphenylthio)-2,3,5,6-tetrafluorobenzene

Base Information

• Chemical Name: 1,4-bis(4-methoxyphenylthio)-2,3,5,6-tetrafluorobenzene
• CAS No.: 1173915-06-4
• Molecular Formula: C₂₀H₁₄F₄O₂S₂
• Molecular Weight: 426.456
• Mol file: 1173915-06-4.mol

Synonyms:1,4-bis(4-methoxyphenylthio)-2,3,5,6-tetrafluorobenzene

Chemical Property of 1,4-bis(4-methoxyphenylthio)-2,3,5,6-tetrafluorobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-bis(4-methoxyphenylthio)-2,3,5,6-tetrafluorobenzene

There total 12 articles about 1,4-bis(4-methoxyphenylthio)-2,3,5,6-tetrafluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Hexafluorobenzene (392-56-3) + S-(4-methoxyphenyl) 4-(dimethylamino)benzenecarbothioate (1258145-46-8) → 1,4-bis(4-methoxyphenylthio)-2,3,5,6-tetrafluorobenzene (1173915-06-4) + 4-(dimethylamino)benzoyl fluoride (108168-59-8)

Guidance literature:

With hydridotetakis(triphenylphosphine)rhodium(I); 1,2-bis-(diphenylphosphino)ethane; In chlorobenzene; for 3h; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.09.009

Reference yield: 86.0%

Pentafluorobenzene (363-72-4) + 4,4'-dimethoxyphenyl disulfide (5335-87-5) → 1,4-bis(4-methoxyphenylthio)-2,3,5,6-tetrafluorobenzene (1173915-06-4)

Guidance literature:

4,4'-dimethoxyphenyl disulfide; With copper(I) bromide; lithium tert-butoxide; In dimethyl sulfoxide; at 20 ℃;

Pentafluorobenzene; With oxygen; In dimethyl sulfoxide; at 60 ℃; for 4h;

DOI:10.1002/ejoc.201101676

Reference yield: 83.0%

Hexafluorobenzene (392-56-3) + S-(4-methoxyphenyl) 4-methoxybenzothioate (98098-60-3) → 1,4-bis(4-methoxyphenylthio)-2,3,5,6-tetrafluorobenzene (1173915-06-4) + p-methoxybenzoyl fluoride (701-53-1)

Guidance literature:

With hydridotetakis(triphenylphosphine)rhodium(I); 1,2-bis-(diphenylphosphino)ethane; In chlorobenzene; for 3h; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.09.009

upstream raw materials:

Hexafluorobenzene

C₁₆H₁₆O₄S

S-(4-methoxyphenyl) 4-(dimethylamino)benzenecarbothioate

S-(4-methoxyphenyl) 4-chlorobenzothioate

Refernces

• 1、 Yu, Chuanming,Hu, Gaobo,Zhang, Cuiling,Wu, Ran,Ye, Haiwei,Yang, Guanghui,Shi, Xiangjun. "Expedient synthesis of tetrafluorophenoxthiines and derivatives by copper(I)-catalyzed cross-coupling reaction". . p. 33 - 38. Retrieved 2013/11/06.
• 2、 Arisawa, Mieko,Yamada, Toru,Yamaguchi, Masahiko. "Rhodium-catalyzed interconversion between acid fluorides and thioesters controlled using heteroatom acceptors". supporting information; experimental part. p. 6090 - 6092. Retrieved 2011/01/04.