[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-acetaldehyde

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Chemical Name:[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-acetaldehyde
CAS No.:1332875-49-6
Molecular Formula:C₂₃H₂₁ClF₃N₅O₂
Molecular Weight:491.9
Hs Code.:

Synonyms:[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-acetaldehyde

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Chemical Property of [2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-acetaldehyde

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Technology Process of [2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-acetaldehyde

There total 11 articles about [2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332875-39-4
2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethanol

: 1332875-49-6
[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-acetaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 13395-36-3
ethyl trimethylacetopyruvate

: 1332875-49-6
[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-acetaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol / 20 - 80 °C

2.1: sulfuryl dichloride / dichloromethane / 20 °C / Inert atmosphere

3.1: sodium hydroxide; water / methanol / 4 h / 20 °C

3.2: pH 7

4.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

5.2: 3 h / Inert atmosphere

6.1: iron / acetic acid / ethanol / 1 h / 100 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 50 °C

8.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

With sulfuryl dichloride; oxalyl dichloride; tetrabutyl ammonium fluoride; water; iron; sodium hydride; Dess-Martin periodane; N,N-dimethyl-formamide; sodium hydroxide; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; mineral oil;

Reference yield:

: 133261-10-6
5-tert-butyl-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

: 1332875-49-6
[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-acetaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuryl dichloride / dichloromethane / 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 4 h / 20 °C

2.2: pH 7

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

4.2: 3 h / Inert atmosphere

5.1: iron / acetic acid / ethanol / 1 h / 100 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 50 °C

7.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

With sulfuryl dichloride; oxalyl dichloride; tetrabutyl ammonium fluoride; water; iron; sodium hydride; Dess-Martin periodane; N,N-dimethyl-formamide; sodium hydroxide; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; mineral oil;