{2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethyl}-dimethyl-amine

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Chemical Name:{2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethyl}-dimethyl-amine
CAS No.:1332875-53-2
Molecular Formula:C₂₅H₂₈ClF₃N₆O
Molecular Weight:520.985
Hs Code.:

Synonyms:{2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethyl}-dimethyl-amine

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Chemical Property of {2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethyl}-dimethyl-amine

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Technology Process of {2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethyl}-dimethyl-amine

There total 12 articles about {2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethyl}-dimethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332875-49-6
[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-acetaldehyde

: 124-40-3
dimethyl amine

: 1332875-53-2
{2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethyl}-dimethyl-amine

Guidance literature:: With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; at 20 ℃; for 18h;

Reference yield:

: 13395-36-3
ethyl trimethylacetopyruvate

: 1332875-53-2
{2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethyl}-dimethyl-amine

Guidance literature:: Multi-step reaction with 9 steps

1.1: ethanol / 20 - 80 °C

2.1: sulfuryl dichloride / dichloromethane / 20 °C / Inert atmosphere

3.1: sodium hydroxide; water / methanol / 4 h / 20 °C

3.2: pH 7

4.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

5.2: 3 h / Inert atmosphere

6.1: iron / acetic acid / ethanol / 1 h / 100 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 50 °C

8.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

9.1: sodium cyanoborohydride; acetic acid / tetrahydrofuran; methanol / 18 h / 20 °C

With sulfuryl dichloride; oxalyl dichloride; tetrabutyl ammonium fluoride; water; iron; sodium hydride; sodium cyanoborohydride; Dess-Martin periodane; acetic acid; N,N-dimethyl-formamide; sodium hydroxide; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; mineral oil;

Reference yield:

: 133261-10-6
5-tert-butyl-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

: 1332875-53-2
{2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethyl}-dimethyl-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuryl dichloride / dichloromethane / 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 4 h / 20 °C

2.2: pH 7

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

4.2: 3 h / Inert atmosphere

5.1: iron / acetic acid / ethanol / 1 h / 100 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 50 °C

7.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

8.1: sodium cyanoborohydride; acetic acid / tetrahydrofuran; methanol / 18 h / 20 °C

With sulfuryl dichloride; oxalyl dichloride; tetrabutyl ammonium fluoride; water; iron; sodium hydride; sodium cyanoborohydride; Dess-Martin periodane; acetic acid; N,N-dimethyl-formamide; sodium hydroxide; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; mineral oil;