2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethanol

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Chemical Name:2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethanol
CAS No.:1332875-39-4
Molecular Formula:C₂₃H₂₃ClF₃N₅O₂
Molecular Weight:493.916
Hs Code.:

Synonyms:2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethanol

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Chemical Property of 2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethanol

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Technology Process of 2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethanol

There total 10 articles about 2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332875-44-1
2-(5-tert-Butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-d]pyridine

: 1332875-39-4
2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 50 ℃; for 18h;

Reference yield:

: 13395-36-3
ethyl trimethylacetopyruvate

: 1332875-39-4
2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethanol / 20 - 80 °C

2.1: sulfuryl dichloride / dichloromethane / 20 °C / Inert atmosphere

3.1: sodium hydroxide; water / methanol / 4 h / 20 °C

3.2: pH 7

4.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

5.2: 3 h / Inert atmosphere

6.1: iron / acetic acid / ethanol / 1 h / 100 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 50 °C

With sulfuryl dichloride; oxalyl dichloride; tetrabutyl ammonium fluoride; water; iron; sodium hydride; N,N-dimethyl-formamide; sodium hydroxide; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; mineral oil;

Reference yield:

: 133261-10-6
5-tert-butyl-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

: 1332875-39-4
2-[2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridin-4-yloxy]-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuryl dichloride / dichloromethane / 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 4 h / 20 °C

2.2: pH 7

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

4.2: 3 h / Inert atmosphere

5.1: iron / acetic acid / ethanol / 1 h / 100 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 50 °C

With sulfuryl dichloride; oxalyl dichloride; tetrabutyl ammonium fluoride; water; iron; sodium hydride; N,N-dimethyl-formamide; sodium hydroxide; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; mineral oil;